Status epilepticus was induced in a group of rats by kainic acid. The study found this action stimulated estradiol synthesis in the hippocampus. The hippocampus is commonly involved in seizures, and estradiol is known to acutely promote neural activity in that region of the brain. Higher estradiol levels were seen in rats experiencing more severe seizures. Through the administration of aromatase inhibitors after seizure onset, both electrographic and behavioral seizures were strongly suppressed. The result suggests that neurosteroid estrogen synthesis may contribute to the escalation of seizures and that the administration of aromatase inhibitors may be an effective treatment.
LKT Labs carries a number of aromatase inhibitors, including the following:
View a full list of the aromatase inhibitors LKT carries here.