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α-Conotoxin GI is a peptide inhibitor of nicotinic acetylcholine receptors (nAChRs) originally found in species of Conus snails. α-Conotoxin GI binds nAChRs at αγ and αδ interfaces. α-Conotoxin GI decreases peak amplitude and induces tetanic and train-of-four fades, modulating acetylcholine signaling at the neuromuscular junction.
| Cas No. | 76862-65-2 |
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| Purity | ≥95% |
| Formula | C55H80N20O18S4 |
| Formula Wt. | 1437.61 |
| Solubility | Soluble in water, PBS. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Hann RM, Pagán OR, Gregory LM, et al. The 9-arginine residue of alpha-conotoxin GI is responsible for its selective high affinity for the alphagamma agonist site on the electric organ acetylcholine receptor. Biochemistry. 1997 Jul 22;36(29):9051-6. PMID: 9220994.
Blount K, Johnson A, Prior C, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42. PMID: 1355934.