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AZD-7648 is a potent, selective inhibitor of DNA-dependent protein kinase (DNA-PK). DNA-PK is a member of the PIKK family, overseeing DNA repair and detection of double-strand breaks. AZD-7648 is being studied as a potential monotherapy or in combination in patients with advanced solid tumors.
| Cas No. | 2230820-11-6 |
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| Purity | ≥98% |
| Formula | C18H20N8O2 |
| Formula Wt. | 380.41 |
| IUPAC Name | 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one |
| Synonym | AZD 7648, AZD7648 |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pspisilova M., Seifrtova M., et al. Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy. J Physiol Pharmacol. 68(3):337-344 (2017). PMID: 28820390.