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CEP-37440 is a dual inhibitor of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK). It inhibits proliferation of some inflammatory breast cancer cell lines in vitro. It may be a good candidate for combination therapy rather than as a monotherapy.
| Cas No. | 1391712-60-9 |
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| Purity | ≥99% |
| Formula | C30H38ClN7O3 |
| Formula Wt. | 580.13 |
| IUPAC Name | 2-{[5-Chloro-2-({(6S)-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl}amino)-4-pyrimidinyl]amino}-N-methylbenzamide |
| Synonym | CEP-37440 Hydrochloride, CEP 37440 Hydrochloride, CEP37440 Hydrochloride |
| Solubility | 10 mM in DMSO |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ott G., Cheng M., et al. Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK). J Med Chem. 59(16):7478-96 (2016). PMID: 27527804.
Salem I., Alsalahi M., et al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breat Cancer Res. 18(1):37 (2016). PMID: 27009091.