LKT Labs

Biochemicals for Life Science Research

Chlortetracycline Hydrochloride

Chlortetracycline Hydrochloride

Product ID C2951
Cas No. 64-72-2
Purity ≥85%
Product Unit SizeCostQuantityStock
5 g $53.00 In stock
25 g $105.00 In stock
100 g $204.00 In stock
Bulk Quote

Quicklinks

Description

Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally, this compound acts as a radical scavenger. In vivo, chlortetracycline suppresses calpain activity and weakly antagonizes NMDA receptor activity and Ca2+ influx, protecting against cerebral ischemia.

Product Info

Cas No.

64-72-2
Purity

≥85%
Formula

C22H23ClN2O8 • HCl
Formula Wt.

515.35
Chemical Name

7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2- naphthacenecarboxamide monohydrochloride

IUPAC Name

(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5, 5a-tetrahydrotetracene-2-carboxamide;hydrochloride
Synonym

Aureociclina, Isphamycin.
Melting Point

>210°C (dec)
Solubility

Soluble at about 28oC of: water (13 mg/mL), methanol (17.4mg/mL) or ethanol (1.7mg/mL).
Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C2951 MSDS PDF
Info Sheet

C2951 Info Sheet PDF

References

Nguyen F, Starosta AL, Arenz S, et al. Tetracycline antibiotics and resistance mechanisms. Biol Chem. 2014 May;395(5):559-75. PMID: 24497223.

Kładna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B4402

    Blasticidin S Hydrochloride

    Protein translation inhibitor.

    ≥98%
  • E7731

    17-α-Ethynylestradiol

    Synthetic steroid hormone; ER agonist.

    ≥99%
  • P2512

    S-(N-Phenethylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • C0266

    Capsaicin, natural

    Found in Capsicum; TRPV agonist.

    ≥95%, capsaicinoids content
  • T1878

    Tetrodotoxin Citrate

    Neurotoxin found in puffer fish; site 1 voltage...

    ≥99%
  • I0482

    S-(+)-Ibuprofen

    Optically active isomer of ibuprofen, NSAID; CO...

    ≥98%
  • A6828

    N(α),N(α)-Dimethyl-L-Arginine Ammonium

    Endogenous amino acid derivative, regulates water/...
    ≥98%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • E543721

    Ensartinib

    A third-generation ALK inhibitor.

    ≥98%
  • A2420

    A-769662

    AMPK activator.

    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%
  • I5213

    Indole-3-carbinol

    Indole, glucosinolate found in cruciferous vege...

    ≥98%
  • L0362

    Lapatinib free base

    Inhibitor of EGFR/HER2 (ErbB2).

    ≥99%
  • T6834

    Triacsin C

    Acyl-CoA synthetase inhibitor.

    ≥95%
  • A5161

    Ampiroxicam

    Piroxicam prodrug, NSAID; COX-1/2 inhibitor.

    ≥98%
  • L2800

    LH846

    Casein kinase 1α/δ/ε inhibitor.

    ≥98%
  • E6398

    EPZ-5676

    DOT1L HMT inhibitor.

    ≥98%
  • F1650

    Fenbendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • W0247

    Walrycin B

    Walrycin response regulator inhibitor.

    ≥98%
  • O938582

    41-Oxo-rapamycin

    Impurity of rapamycin

    ≥95%