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Ginsenoside Re

Ginsenoside Re

Product ID G3457
Cas No. 52286-59-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $152.70 In stock
5 mg $382.10 In stock
10 mg $668.60 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Ginsenoside Re is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-ulcerative, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-diabetic, anti-allergic, cardioprotective, and immunostimulatory activities. Ginsenoside Re inhibits formation of gastric mucosal lesions in vivo by increasing mucosal secretion, decreasing neutrophil infiltration, and suppressing myeloperoxidase and xanthine oxidase activity. In animal models of immunization, ginsenoside Re acts as an adjuvant, increasing the CD4+:CD8+ cell ratio, increasing antibody titers, and increasing levels of IL-4, IL-10, IL-12, and IFN-γ. Ginsenoside Re improves heart rate, perfusion pressure, blood flow, and cardiac output in animal models of myocardial ischemia/reperfusion. Additionally, ginsenoside Re inhibits histamine release in mast cells and decreases LPS-stimulated production of COX-2 and iNOS in microglia. In adipocytes, this compound activates PPARγ signaling, induces adipogenesis, and increases glucose uptake. In vivo, ginsenoside Re inhibits stress-induced anxiety, depression, and cognitive deficits.

Product Info

Cas No.

52286-59-6

Purity

≥98%

Formula

C49H84O17

Formula Wt.

947.18

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,10R,12R,13S,14R, 17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R, 5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2, 3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4, 5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Synonym

Panaxoside RE, Ginsenoside B2

Solubility

Soluble in ethanol (5 mg/ml), DMSO (15 mg/ml), and DMF (20 mg/ml). Insoluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3457 MSDS PDF

Info Sheet

G3457 Info Sheet PDF

References

Su X, Pei Z, Hu S. Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice. Int Immunopharmacol. 2014 Jun;20(2):283-9. PMID: 24680943.

Lee S, Kim MG, Ko SK, et al. Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80. J Ginseng Res. 2014 Apr;38(2):89-96. PMID: 24748832.

Lim KH, Lim DJ, Kim JH. Ginsenoside-Re ameliorates ischemia and reperfusion injury in the heart: a hemodynamics approach. J Ginseng Res. 2013 Jul;37(3):283-92. PMID: 24198653.

Gao Y, Yang MF, Su YP, et al. Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production. J Ethnopharmacol. 2013 May 20;147(2):509-16. PMID: 23545455.

Bae HM, Cho OS, Kim SJ, et al. Inhibitory effects of ginsenoside re isolated from ginseng berry on histamine and cytokine release in human mast cells and human alveolar epithelial cells. J Ginseng Res. 2012 Oct;36(4):369-74. PMID: 23717138.

Lee KW, Jung SY, Choi SM, et al. Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Complement Altern Med. 2012 Oct 26;12:196. PMID: 23102375.

Lee B, Shim I, Lee H, et al. Effect of ginsenoside Re on depression- and anxiety-like behaviors and cognition memory deficit induced by repeated immobilization in rats. J Microbiol Biotechnol. 2012 May;22(5):708-20. PMID: 22561867.

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