Infigratinib Phosphate

Name: Infigratinib Phosphate
SKU: I527211
Availability: InStock

Product ID I527211

Cas No. 1310746-10-1

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Infigratinib phosphate, also known as NVP-BGJ398 is an inhibitor of FGFR that exhibits anticancer chemotherapeutic and antirachitic activities. NVP-BGJ398 inhibits cell viability in colon cancer cells and prevents progression and tumor formation in animal models of malignant rhabdoid tumors. In endometrial cancer cells, NVP-BGJ398 induces cell cycle arrest and inhibits growth; in vivo, it also inhibits tumor growth. NVP-BGJ398 inhibits aberrant FGFR signaling in animal models of rickets disease, normalizing bone growth and mineralization.

Product Info

Cas No.	1310746-10-1
Purity	≥98%
Formula	C₂₆H₃₄Cl₂N₇O₇P
Formula Wt.	658.5
IUPAC Name	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea;phosphoric acid
Synonym	NVP-BGJ398 Phosphate, BGJ-398 phosphate

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I527211 MSDS PDF
Info Sheet	I527211 Info Sheet PDF

References

Turkington RC, Longley DB, Allen WL, et al. Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer. Cell Death Dis. 2014 Feb 6;5:e1046. PMID: 24503538.

Wöhrle S, Weiss A, Ito M, et al. Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. PLoS One. 2013 Oct 30;8(10):e77652. PMID: 24204904.

Konecny GE, Kolarova T, O'Brien NA, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. PMID: 23443805.

Wöhrle S, Henninger C, Bonny O, et al. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res. 2013 Apr;28(4):899-911. PMID: 23129509.

Guagnano V, Furet P, Spanka C, et al. Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. J Med Chem. 2011 Oct 27;54(20):7066-83. PMID: 21936542.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Infigratinib Phosphate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Elvitegravir

LXH254

Linagliptin

2-tert-Butyl-4-Hydroxyanisole

Iohexol

Tivozanib

C-Peptide, human

Baloxavir

Salmeterol

Ginkgolide A

Icilin

Adrenocorticotropic Hormone (1-39), human

Menaquinone-7

EX-527

Icariin

Vardenafil Dihydrochloride

Diosmetin

PHT-427

Methyldopa Sesquihydrate

Telbivudine

Footer