• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LY-2606368

LY-2606368

Product ID L960006
Cas No. 1234015-52-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.30 In stock
25 mg $340.70 In stock
100 mg $885.80 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-2606368 is an inhibitor of checkpoint kinase (CHK) 1. CHK1 is involved in the regulation of cellular response to DNA damage. Inhibitors of CHK1 are being investigated as chemopotentiating agents because of CHK1’s role in establishing DNA damage checkpoints in the cell cycle. LY-2606368 has shown potential as a treatment for squamous cell carcinoma, neuroblastoma, and small-cell lung cancer when used in conjunction with other drugs.

Product Info

Cas No.

1234015-52-1

Purity

≥98%

Formula

C18H19N7O2

Formula Wt.

365.40

Chemical Name

Prexasertib

IUPAC Name

5-({5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)-2-pyrazinecarbonitrile

Synonym

LY 2606368, LY2606368, Prexasertib

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L960006 MSDS PDF

Info Sheet

L960006 Info Sheet PDF

References

Hong D., Infante J., et al. Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer. J Clin Oncol. 34(15):1764-71 (2016). PMID: 27044938.

King C., Diaz H., et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 14(9):2004-13 (2015). PMID: 26141948.

Sen T., Tong P., et al. CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res. 77(14):2870-84 (2017). PMID: 28490518.

Lowery C., VanWye A., et al. The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma. Clin Cancer Res. 23(15):4354-63 (2017). PMID: 28270495.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H1892

    Hexamethylene Bisacetamide

    HEXIM1 activator.

    ≥99%
  • A4931

    3-Aminobenzamide

    PARP inhibitor.

    ≥97%
  • Z160021

    Zearalanone

    Mycotoxin.

    ≥97%
  • A4577

    Alsterpaullone

    GSK-3 and CDK inhibitor.

    ≥98%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • S0368

    Sarcophine

    Cembranoid diterpene found in Sarcophyton glauc...

    ≥98%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • B022691

    Baricitinib

    Selective and reversible JAK inhibitor.

    ≥99%
  • H9715

    Hydroxyurea

    Fetal hemoglobin stimulator; ribonucleotide red...

    ≥98%
  • A9714

    AZD-1152-HQPA

    AurKA/B inhibitor.

    ≥98%
  • L0060

    Lappaconitine

    Alkaloid originally found in species of Aconitu...

    ≥95%
  • O1078

    Octreotide Acetate

    Somatostatin analog, peptide; somatostatin agon...

    ≥95%
  • L1682

    Levamisole Hydrochloride

    Imidazothiazole; alkaline phosphatase inhibitor...

    ≥98%
  • O4658

    Olopatadine Hydrochloride

    Mast cell stabilizer; histamine H1/2/3 antagoni...

    ≥99%
  • T0096

    Cephalomannine

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • V3253

    Vinblastine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥96%
  • S7871

    Stresscopin, human

    Peptide, urocortin III analog; CRFR2 agonist.

    ≥95%
  • D3219

    Diflubenzuron

    Benzoylurea, insect growth regulator; chitin sy...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only