LKT Labs

Biochemicals for Life Science Research

LY-294002 Hydrochloride

LY-294002 Hydrochloride

Product ID L960002
Cas No. 934389-88-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $48.00 In stock
5 mg $102.00 In stock
25 mg $293.00 In stock
100 mg $818.00 In stock
Bulk Quote

Quicklinks

Description

Water soluble form of LY-294002 (L4796). LY-294002 is an inhibitor of PI3K that is used to sensitize cancer cells to other co-administered anticancer chemotherapeutics. In macrophages and monocytes, LY-294002 inhibits NF-κB activity and decreases levels of p50 NF-κB; it also inhibits LPS-induced expression of IL-10. LY-294002 prevents ruffled border formation in osteoclasts by altering the binding of acidic vacuoles with the intercellular membrane. Additionally, this compound inhibits DNA-dependent protein kinase (DPK) activity and prevents the formation of NO.

Product Info

Cas No.

934389-88-5
Purity

≥98%
Formula

C19H17NO3 • HCl
Formula Wt.

343.81
IUPAC Name

2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one hydrochloride (1:1)
Synonym

LY294002 HCl

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L960002 MSDS PDF
Info Sheet

L960002 Info Sheet PDF

References

Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012 Jan 1;83(1):106-14. PMID: 22005520.

Salh B, Wagey R, Marotta A, et al. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol. 1998 Dec 15;161(12):6947-54. PMID: 9862729.

Nakamura I, Sasaki T, Tanaka S, et al. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol. 1997 Aug;172(2):230-9. PMID: 9258344.

Rosenzweig KE, Youmell MB, Palayoor ST, et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997 Jul;3(7):1149-56. PMID: 9815794.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P7628

    Parathyroid Hormone-Related Protein (1-34), human/rat

    Endogenous peptide hormone, increases extracell...

    ≥95%
  • N5770

    Norfloxacin Hydrochloride

    First generation fluoroquinolone antibiotic.

    ≥98%
  • D5709

    Docetaxel

    Semi-synthetic analog of taxol; microtubule dep...

    ≥98%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • S8244

    Sulbactam

    β-lactamase inhibitor.

    ≥98%
  • K5604

    Kobe 0065

    Ras inhibitor.

    ≥99%
  • G720009

    GS-9901

    Selective inhibitor of the delta isoform of PI3...

    ≥99%
  • T3032

    Thienyldecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • H800010

    HU 308

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • R2513

    RGDS

    Tetrapeptide, binds cell surface integrins.

    ≥95%
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • C1644

    Celecoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • F0268

    Farnesol

    Sesquiterpene alcohol found in various essentia...

    ≥98%
  • E9317

    Exemestane

    Aromatase inhibitor.

    ≥97%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • M9646

    Myelin Basic Protein (68-82), guinea pig

    Immunodominant peptide epitope occurring in mul...

    ≥95%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • F5868

    Formoterol Fumarate Dihydrate

    β2-adrenergic agonist.

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%