| Product Unit Size | Cost | Quantity | Stock |
|---|
LY-3295668 is a highly selective Aurora kinase A inhibitor. LY-3295668 has been found to suppress cell proliferation and induce cell-cycle arrest of Merkel cell carcinoma cells in vitro, and attenuate Merkel cell carcinoma xenograft tumor growth in vivo.
| Cas No. | 1919888-06-4 |
|---|---|
| Purity | ≥99% |
| Formula | C24H26ClF2N5O2 |
| Formula Wt. | 489.95 |
| IUPAC Name | (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl]methyl]-2-methylpiperidine-4-carboxylic acid |
| Synonym | LY3295668; AK-01 |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
|---|
Das B, Kannan A, Nguyen Q, et al. Selective inhibition of Aurora kinase A by AK-01/LY3295668 attenuates MCC tumor growth by inducing MCC cell cycle arrest and apoptosis. Cancers (Basel). 2021 Jul 23;13(15):3708. PMID: 34359608
Du J, Torres R, Gong X, et al. Aurora A-selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells, and shows potent preclinical antitumor efficacy. Mol Cancer Ther. 2019 Dec;18(12):2207-2219. PMID: 31530649