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LY-3295668

LY-3295668

Product ID L961000
Cas No. 1919888-06-4
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $104.80 In stock
5 mg $204.00 In stock
10 mg $347.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-3295668 is a highly selective Aurora kinase A inhibitor. LY-3295668 has been found to suppress cell proliferation and induce cell-cycle arrest of Merkel cell carcinoma cells in vitro, and attenuate Merkel cell carcinoma xenograft tumor growth in vivo.

Product Info

Cas No.

1919888-06-4

Purity

≥99%

Formula

C24H26ClF2N5O2

Formula Wt.

489.95

IUPAC Name

(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl]methyl]-2-methylpiperidine-4-carboxylic acid

Synonym

LY3295668; AK-01

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

L961000 Info Sheet PDF

References

Das B, Kannan A, Nguyen Q, et al. Selective inhibition of Aurora kinase A by AK-01/LY3295668 attenuates MCC tumor growth by inducing MCC cell cycle arrest and apoptosis. Cancers (Basel). 2021 Jul 23;13(15):3708. PMID: 34359608

Du J, Torres R, Gong X, et al. Aurora A-selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells, and shows potent preclinical antitumor efficacy. Mol Cancer Ther. 2019 Dec;18(12):2207-2219. PMID: 31530649

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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