Mevinolin

Name: Mevinolin
SKU: M1687
Availability: InStock

Product ID M1687

Cas No. 75330-75-5

Purity ≥97%

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Description

Mevinolin (lovastatin) is a synthetic statin that is also produced by oyster mushrooms and some varieties of rice. Lovastatin inhibits HMG-CoA reductase, preventing cholesterol synthesis; it exhibits anti-hyperlipidemic, anticancer, and antiviral activities. In vitro, lovastatin inhibits proliferation of lymphoma cells, decreasing expression of ROS and transient receptor potential canonical 6 (TRPC6) channels. Additionally, lovastatin inhibits coxsackievirus replication, decreasing expression of coxsackie and adenovirus receptors and preventing viral entry.

Product Info

Cas No.	75330-75-5
Purity	≥97%
Formula	C₂₄H₃₆O₅
Formula Wt.	404.54
Chemical Name	(2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,- 8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalen- yl ester
IUPAC Name	[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3, 7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Synonym	Mevacor, MK-803, Lovalip, Mevinacor, Mevlor, Sivlor, Lovastatin
Melting Point	174.5°C
Solubility	Soluble in acetone and chloroform. Slightly soluble in DMSO (8mg/mL),methanol and ethanol(6mg/mL). Insoluble in water.
Appearance	White to off-white crystalline powder

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Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M1687 MSDS PDF
Info Sheet	M1687 Info Sheet PDF
Brochures	Statins Flyer

References

Song X, Liu BC, Lu XY, et al. Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.
Biochim Biophys Acta. 2014 May;1843(5):894-901. PMID: 24518247.

Werner B, Dittmann S, Funke C, et al. Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells. Inflamm Res. 2014 Apr;63(4):267-76. PMID: 24316867.

Gunde-Cimerman N, Cimerman A. Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. Exp Mycol. 1995 Mar;19(1):1-6. PMID: 7614366.

Alberts AW. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. PMID: 3055919.

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Mevinolin

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