Description
Mevinolin (lovastatin) is a synthetic statin that is also produced by oyster mushrooms and some varieties of rice. Lovastatin inhibits HMG-CoA reductase, preventing cholesterol synthesis; it exhibits anti-hyperlipidemic, anticancer, and antiviral activities. In vitro, lovastatin inhibits proliferation of lymphoma cells, decreasing expression of ROS and transient receptor potential canonical 6 (TRPC6) channels. Additionally, lovastatin inhibits coxsackievirus replication, decreasing expression of coxsackie and adenovirus receptors and preventing viral entry.