Description
Myristicin is an allylbenzene found in spices and umbelliferous plants. Myristicin exhibits anticancer, anti-inflammatory, and antibiotic activities. In leukemia cells, myristicin decreases the mitochondrial membrane potential and increases cytochrome c release and activation of caspase 3 and PARP, inducing apoptosis. In alveolar epithelial cells, myristicin decreases IL-1β-induced production of IL-6. Myristicin also exhibits antibacterial and antifungal efficacy against Clostridium, Enterococcus, Candida, Eubacterium, and Peptostreptococcus. At high doses, myristicin may be neurotoxic.