• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nobiletin

Nobiletin

Product ID N5605
Cas No. 478-01-3
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
25 mg $180.30 In stock
100 mg $563.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nobiletin is a polymethoxylated flavone derived from the peel of citrus fruits. Nobiletin displays anti-inflammatory, anticancer, antioxidative, neuroprotective, cognition enhancing, antidepressant, and anti-obesity properties. In vitro, Nobiletin decreases iNOS expression and levels of NO and also inhibits NF-κB activity. In a variety of cancer cell lines, Nobiletin induces cell cycle arrest and inhibits cellular proliferation through several mechanisms, including inhibition of Ras and MAPK/ERK signaling, downregulation of Bcl-2 and COX-2 levels, upregulation of Bax and caspase-3 expression, and downregulation of matrix metalloproteinase 2 and CXCR4 expression. In aged mice and animal models of Alzheimer’s disease, nobiletin increased glutathione peroxidase and superoxide dismutase activity and decreased phosphorylation of tau, attenuating learning and memory impairments. In other animal models, this compound displays potential use as an antidepressant, attenuating stress-induced deficits in BDNF, TrkB, and synapsin I in the hippocampus. Additionally, nobiletin displays anti-obesity effects in vivo, increasing levels of PPARα/γ, GLUT4, adiponectin, fatty acid synthase, and other enzymes, resulting in decreased body weight gain in overweight animals. Nobiletin may act as a positive allosteric modulator at AMPA receptors by increasing phosphorylation of the GluR1 subunit.

Product Info

Cas No.

478-01-3

Purity

≥97%

Formula

C21H22O8

Formula Wt.

402.39

Chemical Name

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

IUPAC Name

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

Synonym

Hexamethoxyflavone

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N5605 MSDS PDF

Info Sheet

N5605 Info Sheet PDF

References

Yoshigai E, Machida T, Okuyama T, et al. Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes. Biochem Biophys Res Commun. 2013 Sep 13;439(1):54-9. PMID: 23958298.

Nakajima A, Aoyama Y, Nguyen TT, et al. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behav Brain Res. 2013 Aug 1;250:351-60. PMID: 23714077.

Ma X, Jin S, Zhang Y, et al. Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo. Phytother Res. 2013 Jul 1. [Epub ahead of print]. PMID: 23818450.

Aoki K, Yokosuka A, Mimaki Y, et al. Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells. Biol Pharm Bull. 2013;36(4):540-7. PMID: 23546290.

Lee YS, Cha BY, Choi SS, et al. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem. 2013 Jan;24(1):156-62. PMID: 22898571.

Baek SH, Kim SM, Nam D, et al. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9. Pharm Biol. 2012 Oct;50(10):1210-8. PMID: 22853317.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D0182

    Daunorubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • P9870

    Pyridostatin Hydrochloride

    G-quadruplex ligand; DNA breakage inducer.

    ≥97%
  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.

    ≥99%
  • D3357

    Diosmin

    Flavone found in Teucrium.

    ≥95%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • G3558

    20R-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • G3456

    Ginsenoside Rd

    Triterpene saponin found in species of Panax; 2...

    ≥98%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%
  • L5862

    Lopinavir

    HIV protease inhibitor, SERCA inhibitor.

    ≥98%
  • I5992

    IOX2

    Prolyl hydroxylase inhibitor.

    ≥98%
  • P9668

    Pyrantel Pamoate

    Mixture of pyrantel, a thiophene, and pamoic ac...

    ≥98%
  • P2815

    Phenylbutyrate Sodium

    HDAC inhibitor.

    ≥98%
  • U6957

    Urotensin I

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • C1621

    CEF4

    Peptide, vSrc-induced cytokine.

    ≥95%
  • R0110

    Ractopamine Hydrochloride

    β1/2-adrenergic agonist.

    ≥97%
  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • G6368

    GPR

    Peptide, fibrinogen E analog found in Amaranthu...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only