Nocistatin

Name: Nocistatin
SKU: N5211
Availability: BackOrder

Product ID N5211

Cas No.

Purity ≥95%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Nocistatin is a neuromodulatory peptide that exhibits antinociceptive, neuroprotective, and anxiogenic activities. Ca2+-sensitive (BK, IK, SK) K+ channels mediate the inhibitory action of nocistatin on muscle contractions in the uterus. Nocistatin activates transient receptor potential canonical (TRPC) channels via GPCR/PLC/PKC signaling pathways and inhibits thermal hyperalgesia induced by nociceptin. Nocistatin also inhibits memory acquisition impairment induced by nociceptin. Additionally, this peptide inhibits release of 5-HT in synaptosomes and induces anxiogenic activity in animal models undergoing elevated plus maze testing.

Product Info

Purity	≥95%
Formula	C₃₂H₅₆N₁₀O₁₂
Formula Wt.	772.86

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N5211 MSDS PDF
Info Sheet	N5211 Info Sheet PDF
Brochures	TRP Channel Modulator Flyer

References

Deák BH, Klukovits A, Tekes K, et al. Nocistatin inhibits pregnant rat uterine contractions in vitro: roles of calcitonin gene-related peptide and calcium-dependent potassium channel. Eur J Pharmacol. 2013 Aug 15;714(1-3):96-104. PMID: 23792038.

Chen YL, Li AH, Yeh TH, et al. Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons. Mol Cell Neurosci. 2009 Jan;40(1):76-88. PMID: 18930828.

Fantin M, Fischetti C, Trapella C, et al. Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br J Pharmacol. 2007 Oct;152(4):549-55. PMID: 17618307.

Liu EH, Lee TL, Nishiuchi Y, et al. Nocistatin and its derivatives antagonize the impairment of short-term acquisition induced by nociceptin. Neurosci Lett. 2007 Apr 12;416(2):155-9. PMID: 17306455.

Liu EH, Nishiuchi Y, Kimura T, et al. Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice. Neurosci Lett. 2006 Apr 10-17;397(1-2):59-63. PMID: 16384642.

Gavioli EC, Rae GA, Calo' G, et al. Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test. Br J Pharmacol. 2002 Jul;136(5):764-72. PMID: 12086986.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Nocistatin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

KGDS

[His18]-Amylin, rat

Valproic Acid

CYT-387

Atorvastatin Calcium Trihydrate

Puromycin Dihydrochloride

GS-9901

Ionomycin, Free Acid

Prostaglandin E1

18β-Glycyrrhetinic Acid

2′,7-bis(triethylsilyl)taxol

Benzimidazole

Azathioprine

Gestrinone

Peiminine

PluriSIn 1

Bradykinin Triacetate

Substance P (7-11)

Doripenem Hydrate

Pazopanib

Footer