LKT Labs

Biochemicals for Life Science Research

Nocistatin

Nocistatin

Product ID N5211
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $204.40 Please Inquire
10 mg $262.50 Please Inquire
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Quicklinks

Description

Nocistatin is a neuromodulatory peptide that exhibits antinociceptive, neuroprotective, and anxiogenic activities. Ca2+-sensitive (BK, IK, SK) K+ channels mediate the inhibitory action of nocistatin on muscle contractions in the uterus. Nocistatin activates transient receptor potential canonical (TRPC) channels via GPCR/PLC/PKC signaling pathways and inhibits thermal hyperalgesia induced by nociceptin. Nocistatin also inhibits memory acquisition impairment induced by nociceptin. Additionally, this peptide inhibits release of 5-HT in synaptosomes and induces anxiogenic activity in animal models undergoing elevated plus maze testing.

Product Info

Purity

≥95%
Formula

C32H56N10O12
Formula Wt.

772.86

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N5211 MSDS PDF
Info Sheet

N5211 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Deák BH, Klukovits A, Tekes K, et al. Nocistatin inhibits pregnant rat uterine contractions in vitro: roles of calcitonin gene-related peptide and calcium-dependent potassium channel. Eur J Pharmacol. 2013 Aug 15;714(1-3):96-104. PMID: 23792038.

Chen YL, Li AH, Yeh TH, et al. Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons. Mol Cell Neurosci. 2009 Jan;40(1):76-88. PMID: 18930828.

Fantin M, Fischetti C, Trapella C, et al. Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br J Pharmacol. 2007 Oct;152(4):549-55. PMID: 17618307.

Liu EH, Lee TL, Nishiuchi Y, et al. Nocistatin and its derivatives antagonize the impairment of short-term acquisition induced by nociceptin. Neurosci Lett. 2007 Apr 12;416(2):155-9. PMID: 17306455.

Liu EH, Nishiuchi Y, Kimura T, et al. Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice. Neurosci Lett. 2006 Apr 10-17;397(1-2):59-63. PMID: 16384642.

Gavioli EC, Rae GA, Calo' G, et al. Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test. Br J Pharmacol. 2002 Jul;136(5):764-72. PMID: 12086986.

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