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Paeonol

Paeonol

Product ID P0219
Cas No. 552-41-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $41.00 In stock
5 g $132.60 In stock
Bulk Quote

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  • Product Info
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  • Description
  • Product Info
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  • Custom Order

Description

Paeonol was originally found in species of Paeonia, Arisaema, and Dioscorea. Paeonol exhibits anti-inflammatory, analgesic, neuromodulatory, vasodilatory, anticancer, anti-atherosclerotic, and anti-angiogenic activities. Paeonol inhibits carrageenan-induced thermal hyperalgesia and decreases production of TNF-α, IL-1β, COX-2, and iNOS. Paeonol also induces relaxation in aortic rings, potentially through inhibition of voltage-gated and receptor-gated Ca2+ channels. In ovarian cancer cells, paeonol decreases viability by increasing activation of caspase 3, downregulating expression of survivin, and inducing apoptosis. This compound also decreases expression of matrix metalloproteinases 2 and 9 (MMP2/9), suppresses activation of Akt, and prevents migration, tube formation, and vessel formation in vivo and in vitro. Additionally, paeonol decreases release of lactate dehydrogenase, expression of VCAM-1, and activation of JNK1/2, ERK1/2, and p38 MAPK, preventing monocyte adhesion to vascular endothelial cells. Paeonol also inhibits monoamine oxidases A and B (MAO-A, MAO-B).

Product Info

Cas No.

552-41-0

Purity

≥98%

Formula

C9H10O3

Formula Wt.

166.17

Chemical Name

1-(2-Hydroxy-4-methoxyphenyl)ethanone

IUPAC Name

1-(2-hydroxy-4-methoxyphenyl)ethanone

Synonym

4-O-Methylresacetophenone, Resacetophenone-4-methyl ether

Melting Point

49-52°C

Solubility

Soluble in water.

Appearance

Needle White Crystalline Powder with shine

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0219 MSDS PDF

Info Sheet

P0219 Info Sheet PDF

References

Yin J, Wu N, Zeng F, et al. Paeonol induces apoptosis in human ovarian cancer cells. Acta Histochem. 2013 Oct;115(8):835-9. PMID: 23768958.

Wang YQ, Dai M, Zhong JC, et al. Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway. Biol Pharm Bull. 2012;35(5):767-72. PMID: 22687414.

Li YJ, Bao JX, Xu JW, et al. Vascular dilation by paeonol--a mechanism study. Vascul Pharmacol. 2010 Sep-Oct;53(3-4):169-76. PMID: 20643226.

Kim SA, Lee HJ, Ahn KS, et al. Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biol Pharm Bull. 2009 Jul;32(7):1142-7. PMID: 19571375.

Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5. PMID: 15120460.

Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003 Jul;139(6):1146-52. PMID: 12871833.

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