Description
PHT-427 is an inhibitor of PDK1 and Akt that exhibits anticancer chemotherapeutic activity, inhibiting tumor growth in animal models of breast cancer and non-small cell lung cancer (NSCLC).
Product Unit Size | Cost | Quantity | Stock |
---|
PHT-427 is an inhibitor of PDK1 and Akt that exhibits anticancer chemotherapeutic activity, inhibiting tumor growth in animal models of breast cancer and non-small cell lung cancer (NSCLC).
Cas No. | 1191951-57-1 |
---|---|
Purity | ≥98% |
Formula | C20H31N3O2S2 |
Formula Wt. | 409.61 |
Chemical Name | 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide |
IUPAC Name | 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide |
Synonym | PHT427; PHT 427 |
Solubility | DMSO 82 mg/mL (200.19 mM) Ethanol 60 mg/mL (146.48 mM) Water Insoluble |
Appearance | White Crystal Powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Meuillet EJ, Zuohe S, Lemos R, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17. PMID: 20197390.
Insect growth regulator; chitin synthesis inhib...
NSAID; COX-1/2 inhibitor.
DNA alkylator.
BHA derivative, antioxidative food and cosmetic...
M3 mAChR antagonist.
Synthetic progestogen, orexigenic.
Aminoglycoside; protein translation inhibitor.<...
Synthesis impurity
Diterpene found in roasted coffee.
NSAID; COX-1/2 inhibitor.
Octapeptide, prevents EGFR-PLCγ association.
AT1 antagonist.
Semisynthetic flavone that acts as an inhibitor...
Synthetic steroid hormone; ER agonist.
Synthetic steroid, contraceptive; PR and glucoc...
Endogenous peptide, involved in stress signalin...
Triazolopyrazine; c-MET inhibitor.
PI3K inhibitor.
Endogenous purine nucleotide base, required for...
Peptide found in molluscs, cardiomodulator.