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Pixantrone Dimaleate

Pixantrone Dimaleate

Product ID P3592
Cas No. 144675-97-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $180.00 In stock
25 mg $337.10 In stock
100 mg $898.60 In stock
Bulk Quote

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  • Product Info
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  • Description
  • Product Info
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  • Downloads
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  • Custom Order

Description

Pixantrone is an anticancer chemotherapeutic and immunosuppressive aza-anthracenedione that acts as a DNA intercalator and topoisomerase II inhibitor; this compound intercalates via the major or minor grooves of DNA, binding to CpG or CpA motifs. In cellular models, pixantrone inhibits proliferation of T cells, but does not affect differentiation of dendritic cells or B cells. In clinical trials, pixantrone increases survival times of patients with relapsed or refractory aggressive non-Hodgkin’s B-cell lymphoma. Pixantrone also shows potential benefit in the treatment of several other diseases. In cellular models, this compound decreases or prevents amyloid-β (Aβ) oligomerization, indicating a potential use in the treatment of Alzheimer’s disease. Additionally, it decreases acetylcholine receptor (AChR)-specific immune responses and prevents and treats experimental autoimmune encephalitis (EAE) in animal models, suggesting potential benefit in the treatment of myasthenia gravis and multiple sclerosis.

Product Info

Cas No.

144675-97-8

Purity

≥98%

Formula

C17H19N5O2 • (C4H4O4)2

Formula Wt.

557.51

Chemical Name

6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione

IUPAC Name

6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione;(Z)-but-2-enedioic acid

Synonym

5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione, BBR2778

Appearance

Dark Purple Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P3592 MSDS PDF

Info Sheet

P3592 Info Sheet PDF

References

Péan E, Flores B, Hudson I, et al. The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. Oncologist. 2013;18(5):625-33. PMID: 23615696.

Marolda R, Ruocco C, Cordiglieri C, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013 May 15;258(1-2):41-50. PMID: 23523328.

Adnan N, Buck DP, Evison BJ, et al. DNA binding by pixantrone. Org Biomol Chem. 2010 Dec 7;8(23):5359-66. PMID: 20865205.

Colombo R, Carotti A, Catto M, et al. CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis. 2009 Apr;30(8):1418-29. PMID: 19306269.

Evison BJ, Chiu F, Pezzoni G, et al. Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets. Mol Pharmacol. 2008 Jul;74(1):184-94. PMID: 18413664.

Gonsette RE, Dubois B. Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. J Neurol Sci. 2004 Aug 15;223(1):81-6. Review. PMID: 15261566.

Custom Order

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