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Pluripotin is a dual kinase and GTPase inhibitor. Pluripotin promotes self-renewal in murine embryonic stem cells without the necessity of Leukemia Inhibitory Factor (LIF). Its self-renewal preservation properties have been used to aid in the study of both pluripotency and cancer stem cells (CSCs). It has also been found to promote self-renewal in chicken blastodermal cells by inhibiting ERK1 phosphorylation and promoting Akt phosphorylation.
| Cas No. | 839707-37-8 |
|---|---|
| Purity | ≥98% |
| Formula | C27H25F3N8O2 |
| Formula Wt. | 550.55 |
| Chemical Name | N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide |
| IUPAC Name | N-(3-{7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl}-4-methylphenyl)-3-(trifluoromethyl)benzamide |
| Synonym | SC1; SC-1; Stemolecule SC 1 |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chen S., Do J., et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA. 103(46);17266-71 (2006). PMID: 17088537.
Mertins S., Scudiero D., et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 8(2):e57099 (2013). PMID: 23437320.
Li R., Tang X., et al. Reprod Domest Anim. 53(5):1052-59 (2018). PMID: 30028046.