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Pluripotin

Pluripotin

Product ID P465822
Cas No. 839707-37-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $65.10 In stock
5 mg $131.30 In stock
25 mg $336.00 In stock
100 mg $892.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pluripotin is a dual kinase and GTPase inhibitor. Pluripotin promotes self-renewal in murine embryonic stem cells without the necessity of Leukemia Inhibitory Factor (LIF). Its self-renewal preservation properties have been used to aid in the study of both pluripotency and cancer stem cells (CSCs). It has also been found to promote self-renewal in chicken blastodermal cells by inhibiting ERK1 phosphorylation and promoting Akt phosphorylation.

Product Info

Cas No.

839707-37-8

Purity

≥98%

Formula

C27H25F3N8O2

Formula Wt.

550.55

Chemical Name

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

IUPAC Name

N-(3-{7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl}-4-methylphenyl)-3-(trifluoromethyl)benzamide

Synonym

SC1; SC-1; Stemolecule SC 1

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P465822 MSDS PDF

Info Sheet

P465822 Info Sheet PDF

References

Chen S., Do J., et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA. 103(46);17266-71 (2006). PMID: 17088537.

Mertins S., Scudiero D., et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 8(2):e57099 (2013). PMID: 23437320.

Li R., Tang X., et al. Reprod Domest Anim. 53(5):1052-59 (2018). PMID: 30028046.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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