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Vinorelbine Base

Vinorelbine Base

Product ID V3251
Cas No. 71486-22-1
Purity ≥90%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $255.30 In stock
25 mg $714.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vinorelbine is a semi-synthetic vinca alkaloid originally found in Catharanthus that exhibits anticancer chemotherapeutic activity. Vinorelbine binds β-tubulin and stimulates microtubule depolymerization, acting as an anti-mitotic. Vinorelbine is clinically used to treat breast cancer and non-small cell lung cancer (NSCLC). In osteosarcoma cells, vinorelbine downregulates expression of cyclin D1 and upregulates expression of p53, inhibiting cell growth.

Product Info

Cas No.

71486-22-1

Purity

≥90%

Formula

C45H54N4O8

Formula Wt.

778.93

Chemical Name

3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine

IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(12S,14R)-16-ethyl-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

Synonym

Vinorelbine, NavelbineR, KW 2307, nor-5'-anhydrovinblastine, NVB

Appearance

Light brown powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V3251 MSDS PDF

Info Sheet

V3251 Info Sheet PDF

References

Capasso A. Vinorelbine in cancer therapy. Curr Drug Targets. 2012 Jul;13(8):1065-71. PMID: 22594474.

Roncuzzi L, Marti G, Baiocchi D, et al. Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. Oncol Rep. 2006 Jan;15(1):73-7. PMID: 16328036.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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