Prednisolone

Name: Prednisolone
SKU: P6818
Availability: InStock

Product ID P6818

Cas No. 50-24-8

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

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Description

Prednisolone is a derivative of cortisol and a metabolite of prednisone; it exhibits immunosuppressive and anti-inflammatory activities. Prednisolone activates glucocorticoid receptors and is clinically used to treat inflammatory and autoimmune disorders. In mononuclear cells from subjects with multiple sclerosis, prednisolone decreases expression of T-bet, IFNγ, and phosphorylated STAT1, decreasing lymphocyte apoptosis. Additionally, prednisolone delays the progression of Duchenne muscular dystrophy (DMD), altering muscle fiber types in vivo.

Product Info

Cas No.	50-24-8
Purity	≥98%
Formula	C₂₁H₂₈O₅
Formula Wt.	360.44
Chemical Name	(11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
IUPAC Name	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10, 13-dimethyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Synonym	Cortalone, Decaprednil, Decortin H, Deltasolone, Flamasone, Hydrodeltalone, Paracortol, Sterolone
Melting Point	240-241°C(dec)
Solubility	Slightly soluble in water (1 mM). Soluble in methanol and dioxane. Soluble in ethanol (33 mg/mL), DMSO (633 mM)
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P6818 MSDS PDF
Info Sheet	P6818 Info Sheet PDF

References

Frisullo G, Nociti V, Iorio R, et al. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin Immunol. 2007 Sep;124(3):284-93. PMID: 17627892.

Fisher I, Abraham D, Bouri K, et al. Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J. 2005 May;19(7):834-6. Erratum in: FASEB J. 2005 May;19(7):1 p following 836. Hoffmann, Eric P [corrected to Hoffman, Eric P]. PMID: 15734791.

Davis M, Williams R, Chakraborty J, et al. Prednisone or prednisolone for the treatment of chronic active hepatitis? A comparison of plasma availability. Br J Clin Pharmacol. 1978 Jun;5(6):501-5. PMID: 656293.

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Prednisolone

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