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Kyotorphin is an opioid neuropeptide that exhibits analgesic, antinociceptive, vasodilatory, and antihypertensive activities. Kyotorphin binds the kyotorphin receptor, which is coupled to Gi GPCRs, altering downstream PLC signaling and met-enkephalin release.
| Cas No. | 70904-56-2 |
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| Purity | ≥95% |
| Formula | C15H23N5O4 |
| Formula Wt. | 337.4 |
| IUPAC Name | (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| Synonym | KTP |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Miguel M, Manso M, Aleixandre A, et al. Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and antihypertensive properties of peptides derived from egg white. J Agric Food Chem. 2007 Dec 26;55(26):10615-21. PMID: 18047278.
Ueda H, Inoue M. In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx. Mol Pharmacol. 2000 Jan;57(1):108-15. PMID: 10617685.
Satoh M, Wada T, Iwama T, et al. Sites of analgesic actions of kyotorphin and D-kyotorphin in the central nervous system of rats. Neuropeptides. 1985 Feb;5(4-6):415-8. PMID: 4000414.