Canertinib Dihydrochloride

Name: Canertinib Dihydrochloride
SKU: C0252
Availability: InStock

Product ID C0252

Cas No. 289499-45-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Canertinib is an irreversible inhibitor of EGFR (HER2/ErbB). This compound is currently in clinical trials as an anticancer chemotherapeutic, displaying activity against a variety of cancers. In a cellular model of melanoma, canertinib exhibits cytostatic activity, stopping cell growth in the G1 phase, but not inducing apoptosis except at very high concentrations. In a related animal model, canertinib inhibits tumor growth. Separately, canertinib inhibits Akt and ERK1/2 in cells lacking ErbB receptors and induces caspase-mediated apoptosis.

Product Info

Cas No.	289499-45-2
Purity	≥98%
Formula	C₂₄H₂₅ClFN₅O₃ • 2HCl
Formula Wt.	558.86
Chemical Name	N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6- yl]prop-2-enamide;dihydrochloride
IUPAC Name	N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6- yl]prop-2-enamide;dihydrochloride
Synonym	CI1033
Appearance	Pale yellow powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C0252 MSDS PDF
Info Sheet	C0252 Info Sheet PDF
Brochures	PI3K-Akt-mTORC Pathway Booklet
	Ras-Raf-MEK-ERK Pathway Booklet

References

Djerf Severinsson EA, Trinks C, Gréen H, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8. PMID: 21982771.

Trinks C, Severinsson EA, Holmlund B, et al. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):422-7. PMID: 21669187.

Zinner RG, Nemunaitis J, Eiseman I, et al. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2007 May 15;13(10):3006-14. PMID: 17505003.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Canertinib Dihydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

GS-4997

Montelukast Sodium

Berteroin

Citreoviridin A

Vinorelbine Base

Carmofur

Bradykinin (1-3)

(−)-Gallocatechin

Bupivacaine

Pizotyline Malate

Antipain Dihydrochloride

4-(Methylsulfinyl) butylamine

Fenoldopam Mesylate

Bisacodyl

Ramoplanin

4-Aminosalicylic Acid

Tubastatin A Hydrochloride

AMG-208

α-Conotoxin GI

Bafilomycin A1

Footer