LKT Labs

Biochemicals for Life Science Research

Verbascoside

Verbascoside

Product ID V1869
Cas No. 61276-17-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $128.00 In stock
5 mg $245.00 In stock
10 mg $367.00 In stock
25 mg $715.00 In stock
Bulk Quote

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Description

Verbascoside is a phenylpropanoid found in a variety of species of Castilleja, Verbena, and Verbascum. Verbascoside displays anti-inflammatory, analgesic, antioxidative, and antithrombotic properties in a variety of cellular and animal models. In vitro, verbascoside inhibits arachidonic acid- and ADP-induced platelet aggregation as well as dipeptidyl peptidase 4 (DPP4) and prolyl oligopeptidase activity. In vivo, verbascoside decreases levels of Bax, Bcl-2, NF-κB, iNOS, and myeloperoxidase, showing anti-inflammatory benefit in a model of periodontitis. Additionally, this compound inhibits mechanical pain in two different animal models of hyperalgesia. Verbascoside may also be an inhibitor of PKC.

Product Info

Cas No.

61276-17-3
Purity

≥98%
Formula

C29H36O15

Formula Wt.

624.59
Chemical Name

[(2R,3R,4R,5R,6R)-6-[2-(3, 4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R, 6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
IUPAC Name

[(2R,3R,4R,5R,6R)-6-[2-(3, 4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R, 6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Synonym

Acteoside, Kusaginin
Appearance

Off-white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

V1869 MSDS PDF
Info Sheet

V1869 Info Sheet PDF

References

Campo G, Marchesini J, Bristot L, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012 Oct;34(3):318-25. PMID: 22723176.

Filho AG, Morel AF, Adolpho L, et al. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytother Res. 2012 Oct;26(10):1472-5. PMID: 22275311.

Paola RD, Oteri G, Mazzon E, et al. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. J Pharm Pharmacol. 2011 May;63(5):707-17. PMID: 21492173.

Isacchi B, Iacopi R, Bergonzi MC, et al. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. PMID: 21401613.

Kahraman C, Tatli II, Orhan IE, et al. Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Z Naturforsch C. 2010 Nov-Dec;65(11-12):667-74. PMID: 21319708.

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