LKT Labs

Biochemicals for Life Science Research

Indomethacin

Indomethacin

Product ID I5315
Cas No. 53-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $55.30 In stock
10 g $101.90 In stock
25 g $181.50 In stock
100 g $405.20 In stock
Bulk Quote

Quicklinks

Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, tocolytic, and anti-metastatic activities. Indomethacin is a non-selective COX-1 and COX-2 inhibitor that is clinically used to treat headaches; like other NSAIDs, indomethacin may induce intestinal damage or gastric lesions. Indomethacin delays premature labor in clinical settings by decreasing uterine contractility. In vitro, indomethacin decreases cancer cell migration by suppressing Ca2+ influx.

Product Info

Cas No.

53-86-1
Purity

≥98%
Formula

C19H16ClNO4
Formula Wt.

357.79
Chemical Name

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid
IUPAC Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Synonym

Amuno, Idomethine.
Melting Point

158-162°C
Solubility

Insoluble in water. Soluble in ethanol (20 mg/mL), or acetone.
Appearance

White/Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5315 MSDS PDF
Info Sheet

I5315 Info Sheet PDF

References

Adewoye EO, Salami AT. Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Niger J Physiol Sci. 2013 Dec 20;28(2):193-9. PMID: 24937396.

Guo YC, Chang CM, Hsu WL, et al. Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules. 2013 Jun 4;18(6):6584-96. PMID: 23736792.

Summ O, Evers S. Mechanism of action of indomethacin in indomethacin-responsive headaches. Curr Pain Headache Rep. 2013 Apr;17(4):327. PMID: 23423598.

Giles W, Bisits A. Preterm labour. The present and future of tocolysis. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):857-68. PMID: 17459777.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • S0930

    Schisantherin A

    Dibenzocyclooctadiene found in Schisandra.

    ≥98%
  • C6955

    Cromolyn Sodium

    Mast cell destabilizer; potential TRP antagonis...

    ≥99%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%
  • G1745

    Gemcitabine Hydrochloride

    Nucleoside (deoxycytidine) analog; ribonucleoti...

    ≥98%
  • M4100

    MK-0524

    DP1 antagonist.

    ≥99%
  • Z324098

    Ziconotide

    Non-opioid analgesic.

    ≥95%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • A491337

    9-Aminocamptothecin Hydrochloride

    Derivative of camptothecin.

    ≥98%
  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • P3018

    Phellodendrine

    Quaternary base alkaloid found in Phellodendron...

    ≥98%
  • N7332

    NSI-189

    Stem cell neurogenesis inducer.

    ≥99%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • D3362

    Dipyridamole

    PDE and adenosine deaminase inhibitor.

    ≥98%
  • A724091

    Asciminib

    Allosteric inhibitor

    ≥98%
  • H9726

    Hygromycin B

    Protein translocation inhibitor.

    ≥95.0%
  • S041001

    SB-202190

    Highly selective inhibitor

    ≥99%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%