Disulfiram

Name: Disulfiram
SKU: D3374
Availability: InStock

Product ID D3374

Cas No. 97-77-8

Purity ≥98%

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Description

Disulfiram is an inhibitor of aldehyde dehydrogenase that is clinically used to treat chronic alcohol dependence. Disulfiram prevents complete metabolism of alcohol, allowing acetaldehyde to build up. Disulfiram also exhibits anticancer and anti-parasitic activities. This compound inhibits the 26S proteasome, activating caspases 3 and 7 and inducing apoptosis in chronic lymphocytic leukemia (CLL), non-small cell lung cancer (NSCLC), ovarian cancer, and breast cancer cells. Disulfiram also inhibits MGMT, potentially enhancing the efficacy of other co-administered chemotherapeutics. Additionally, disulfiram inhibits the growth of protozoans Trichomonas and Tritrichomonas.

Product Info

Cas No.	97-77-8
Purity	≥98%
Formula	C₁₀H₂₀N₂S₄
Formula Wt.	296.54
Chemical Name	Tetraethylthioperoxydicarbonic diamide
IUPAC Name	diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Synonym	Tetraethylthiuram disulfide, Teturamin, TTD, Cronetal, Abstensil, Antadix, Antietanol, Exhoran, Antabuse, Etabus, Esperal, Tetradine, Noxal, Tetraetil
Melting Point	70°C
Solubility	Soluble in alcohol (330 mg/mL), ether, acetone, benzene, or chloroform. Practically insoluble in water.
Appearance	Light yellow crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	D3374 MSDS PDF
Info Sheet	D3374 Info Sheet PDF

References

Paranjpe A, Zhang R, Ali-Osman F, et al. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. PMID: 24193513.

Wickström M, Danielsson K, Rickardson L, et al. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. 2007 Jan 1;73(1):25-33. PMID: 17026967.

Bouma MJ, Snowdon D, Fairlamb AH, et al. Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20. PMID: 10052908.

Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990 Jun;88(6):647-55. Review. Erratum in: Am J Med 1991 Oct;91(4):446. PMID: 2189310.

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Disulfiram

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