LKT Labs

Biochemicals for Life Science Research

β-Elemene

β-Elemene

Product ID E4418
Cas No. 515-13-9
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 In stock
100 mg $204.30 In stock
500 mg $714.70 In stock
Bulk Quote

Quicklinks

Description

β-Elemene is a sesquiterpene found in various plant sources. This compound exhibits anti-angiogenic and anticancer chemotherapeutic properties by suppressing Notch-1 and decreasing the expression and phosphorylation of Smad3 and altering TGF-β 1 signaling. β-Elemene also displays anti-inflammatory and immunomodulatory properties, suppressing differentiation of Th17 cells and decreasing levels of IL-17, IL-6, and IL-23 in a mouse model of multiple sclerosis. This compound also induces apoptosis and cell cycle arrest in a wide variety of cancer cell lines.

Product Info

Cas No.

515-13-9
Purity

≥98%
Formula

C15H24
Formula Wt.

204.35
Chemical Name

1S,2S,4R)-1-Methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
IUPAC Name

1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane
Appearance

Clear and colorless liquid

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

E4418 MSDS PDF
Info Sheet

E4418 Info Sheet PDF

References

He J, Li M, Bao J, et al. β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. Front Pharmacol. 2024 Oct 17:15:1469180. PMID: 39484165.

Yan B, Zhou Y, Feng S, et al. β -Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells. Evid Based Complement Alternat Med. 2013;2013:268468. PMID: 23710217.

Zhang X, Li Y, Zhang Y, et al. Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors. PLoS One. 2013;8(3):e58719. PMID: 23516540.

Dai ZJ, Tang W, Lu WF, et al. Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int. 2013 Mar 14;13(1):27. PMID: 23496852.

Zhang R, Tian A, Zhang H, et al. Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance. J Mol Neurosci. 2011 May;44(1):31-40. PMID: 21246417.

Li QQ, Wang G, Huang F, et al. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27. PMID: 20663036.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C5618

    Coelenterazine, natural

    Light-emitting luciferin analog found in aquati...

    ≥98%
  • D3430

    Dihydrosanguinarine

    Benzophenanthridine alkaloid, sanguinarine meta...

    ≥98%
  • I5215

    Indolicidin

    Antimicrobial peptide.

    ≥95%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • C5773

    Cortistatin-14

    Endogenous neuropeptide, somatostatin analog; s...

    ≥95%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • B8070

    2-tert-Butyl-4-Hydroxyanisole

    BHA derivative, antioxidative food and cosmetic...

    ≥99% single isomer
  • F1895

    Fexofenadine Hydrochloride

    Histamine H1 antagonist.

    ≥98%
  • G3462

    Ginsenoside F3

    Triterpene saponin found in species of Panax.

    ≥98%
  • A4847

    Amylin, human

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • O486179

    Omeprazole Impurity C

    Impurity of omeprazole

    ≥99%
  • P0144

    Paliperidone

    D2 and 5-HT2A antagonist.

    ≥97%
  • T3468

    Tirapazamine

    Topoisomerase II inhibitor, RPA modulator.

    ≥98%
  • A4438

    Allatostatin I

    Neuropeptide found in insects; juvenile hormone...

    ≥95%
  • I5072

    Imazalil

    Triazole; 14-α demethylase and aromatase inhib...

    ≥95%, titration; ≥70%, HPLC
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • S680000

    SR144528

    Selective cannabinoid receptor 2 (CB2) inverse ...

    ≥98%
  • G8225

    Guggulsterone

    Steroid found in myrrh; FXR antagonist.

    ≥98%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%