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10-Deacetybaccatin III is a diterpene found in Taxus that exhibits analgesic, anti-inflammatory, and anti-parasitic activities. In vivo, this compound decreases edema as well as pain scores in the acid-induced writing test. 10-Deacetylbaccatin III also induces G2/M phase cell cycle arrest and inhibits growth in Leishmania.
| Cas No. | 32981-86-5 |
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| Purity | ≥98% |
| Formula | C29H36O10 |
| Formula Wt. | 544.59 |
| IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| Synonym | 10-DB III, 10-Deacetylbaccatine III, Docetaxel impurity E; 10-deacetylbaccatin; 10-deacetyl-baccatin; 10-DAB. |
| Melting Point | 230-233°C |
| Solubility | Soluble in DMSO. |
| Appearance | White to off white crystalline powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6. PMID: 21953729.
Georgopoulou K, Smirlis D, Bisti S, et al. In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes. Planta Med. 2007 Aug;73(10):1081-8. PMID: 17691059.