• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
17-Allylaminogeldanamycin

17-Allylaminogeldanamycin

Product ID A0025
Cas No. 75747-14-7
Purity ≥97%
Product Unit SizeCostQuantityStock
0.5 mg $58.20 In stock
1 mg $68.10 In stock
5 mg $112.90 In stock
25 mg $286.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Geldanamycin derivative 17-AAG is an inhibitor of heat shock protein 90 (HSP90) that exhibits anti-inflammatory, anticancer chemotherapeutic, and antiviral activities. In endothelial cells, 17-AAG induces degradation of IκBα, attenuating NF-κB activation. 17-AAG induces Bax-dependent apoptosis in a variety of cancer models, both in vitro as well as in vivo. Additionally, 17-AAG inhibits replication of human cytomegalovirus.

Product Info

Cas No.

75747-14-7

Purity

≥97%

Formula

C31H43N3O8

Formula Wt.

585.69

IUPAC Name

[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9, 15-tetramethyl-16,20, 22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate

Synonym

17-(Allylamino)-17-desmethoxy-geldanamycin, allylaminogeldanamycin, 17-AAG, telatinib.

Melting Point

200-205°C

Solubility

Soluble in DMSO or methanol.

Appearance

Purple powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A0025 MSDS PDF

Info Sheet

A0025 Info Sheet PDF

References

Thangjam GS, Dimitropoulou C, Joshi AD, et al. Novel mechanism of attenuation of LPS-induced NF-κB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol. 2014 May;50(5):942-52. PMID: 24303801.

Powers MV, Valenti M, Miranda S, et al. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. 2013 Nov;4(11):1963-75. PMID: 24185264.

Evers DL, Chao CF, Zhang Z, et al. 17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells. Arch Virol. 2012 Oct;157(10):1971-4. PMID: 22711259.

Gloesenkamp C, Nitzsche B, Lim AR, et al. Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors. Int J Oncol. 2012 May;40(5):1659-67. PMID: 22246317.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G337543

    Ginsenoside CK

    Major metabolite of ginsenosides Rb1, Rb2, Rc, ...

    ≥98%
  • V3326

    Virginiamycin S1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥99%
  • J0379

    Jatrorrhizine Chloride

    Alkaloid compound originally found in Corydalis...

    ≥95%
  • H9662

    Hypocrellin B

    Induces DNA strand breakage.

    ≥98%
  • B8112

    Budesonide

    Steroid; glucocorticoid agonist.

    ≥97%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%
  • A6982

    Artesunate

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • H0002

    H8 dihydrochloride

    PKA inhibitor.

    ≥98%
  • C9808

    CZC-54252

    LRRK2 inhibitor.

    ≥98%
  • C9670

    Cyromazine

    Triazine, melamine derivative, insect growth re...

    ≥98%
  • T0394

    (+)-Taxifolin

    Catechol-type flavonoid; fatty acid synthesis i...

    ≥98%
  • P6865

    Propranolol Hydrochloride

    β1/2-adrenergic antagonist.

    ≥98%
  • T0119

    Taxol Side Chain β-lactam

    Taxol synthesis intermediate.

    ≥98%
  • E7329

    Ethoxyquin

    Quinoline, food preservative; HSP90 inhibitor.<...

    ≥90%
  • A4445

    Allopurinol

    Purine (hypoxanthine) analog; xanthine oxidase ...

    ≥98%
  • H1695

    S-Hexylglutathione

    Glutathione-S-transferase inhibitor.

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • L1784

    Levetiracetam

    SV2A synaptic vesicle inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only