Description
2′,7-bis(triethylsilyl)taxol is an intermediate in the synthesis of the anti-cancer therapeutic, taxol (paclitaxel) and its derivatives.
Product Unit Size | Cost | Quantity | Stock |
---|
2′,7-bis(triethylsilyl)taxol is an intermediate in the synthesis of the anti-cancer therapeutic, taxol (paclitaxel) and its derivatives.
Cas No. | 135365-62-7 |
---|---|
Purity | ≥98% |
Formula | C59H79NO14Si2 |
Formula Wt. | 1082.44 |
Chemical Name | 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate] |
IUPAC Name | (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-1-hydroxy-9-oxo-7-[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate |
Synonym | 2',7-di-TES-paclitaxel, (2'R,3'S)-2',7-(bis)triethylsilyl taxol; 2’,7-bis(triethylsilyl)Paclitaxel |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.
Inhibitor of CDK.
Synthetic steroid hormone; AR agonist, ER and P...
Butyrophenone; α-adrenergic, D2, histamine ant...
Endogenous peptide, involved in paracrine and a...
Potential voltage-gated Na+ channel blocker.
Cysteine-ITC conjugate, antioxidant; HDAC inhib...
GSK-3β, HGK, and CDK inhibitor.
Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...
Cyclic depsipeptide is a secondary metabolite i...
Endogenous opioid peptide; δOR and μOR agonis...
Thienylbutyl ITC analog.
Cyclosporin metabolite; weak calmodulin inhibit...
Peptide, used to deliver conjugated drugs to ce...
Endogenous quaternary ammonium, required for fa...
Serum response factor inhibitor and MRTF-A bind...
Polyphenolic compound present in black tea.
Taxane found in species of Taxus; potential mic...
Cysteine-ITC conjugate, antioxidant.
Oligopeptide found in Actinomycetes; protease i...
Diterpene found in brewed, unfiltered coffee; F...