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4-Phenylbutylisothiocyanate

4-Phenylbutylisothiocyanate

Product ID P2510
Cas No. 61499-10-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $92.00 In stock
5 g $357.30 In stock
10 g $653.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

4-Phenylbutyl isothiocyanate (ITC) is a synthetic ITC that exhibits anticancer chemotherapeutic and chemopreventive activities. In vitro, this compound induces caspase 3-dependent apoptosis. 4-Phenylbutyl isothiocyanate inhibits the development of pancreatic dysplasia and adenocarcinoma in animal models; in other animals, it decreases the number of already formed lung tumors. Like other ITCs, this compound also acts as a phase II enzyme inducer.

Product Info

Cas No.

61499-10-3

Purity

≥98%

Formula

C11H13NS

Formula Wt.

191.31

Chemical Name

4-isothiocyanatobutylbenzene

IUPAC Name

4-isothiocyanatobutylbenzene

Synonym

Solubility

Soluble in DMSO.

Appearance

Colorless or slightly yellowish liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2510 MSDS PDF

Info Sheet

P2510 Info Sheet PDF

References

Son HY, Nishikawa A, Furukawa F, et al. Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters. Cancer Lett. 2000 Nov 28;160(2):141-7. PMID: 11053643.

Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.

Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.

Custom Order

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