Description
4-Thiouridine is a modified nucleotide that induces DNA cross-linking after irradiation with UV light. This compound is often used for labeling DNA in research models.
4-Thiouridine
Product ID T2933
Cas No. 13957-31-8
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 13957-31-8 |
|---|---|
| Purity | ≥98% |
| Formula | C9H12N2O5S |
| Formula Wt. | 260.27 |
| Chemical Name | Uridine, 4-thio- (8CI)(9CI) |
| IUPAC Name | 1-[3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one |
| Synonym | Thiouridine |
| Melting Point | 141-143°C |
| Solubility | Soluble in water (20 mg/mL), ethanol (2 mg/mL), DMSO (10 mg/mL). |
| Appearance | Yellowish crystalline powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Wang L, Ruffner DE. An ultraviolet crosslink in the hammerhead ribozyme dependent on 2-thiocytidine or 4-thiouridine substitution. Nucleic Acids Res. 1997 Nov 1;25(21):4355-61. PMID: 9336468.
Ofengand J, Liou R, Kohut J 3rd, et al. Covalent cross-linking of transfer ribonucleic acid to the ribosomal P site. Mechanism and site of reaction in transfer ribonucleic acid. Biochemistry. 1979 Oct 2;18(20):4322-32. PMID: 385051.