LKT Labs

Biochemicals for Life Science Research

A 83-01

Product ID A001001
Cas No. 909910-43-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $75.00 In stock
25 mg $245.00 In stock
100 mg $750.00 In stock
Bulk Quote

Quicklinks

Description

A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.

Product Info

Cas No.

909910-43-6
Purity

≥98%
Formula

C25H19N5S
Formula Wt.

421.52
Chemical Name

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
IUPAC Name

3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Synonym

A83-01; ALK5 Inhibitor IV; 1H-Pyrazole-1-carbothioamide,3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
Solubility

Soluble in DMSO 1mg/mL in ethanol 2.5mg/mL in ethyl acetate
Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A001001 MSDS PDF
Info Sheet

A001001 Info Sheet PDF

References

Katsuda T, Kawamata M, Hagiwara K, et al. Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. PMID: 27840021.

Wang H, Liu S, Wang Y, et al. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016 Jan 14;16(2):126-131. PMID: 26773180.

Nishino Y, Murakami M, Funaba M. Expression and role of the TGF-beta family in glial cells infected with Borna disease virus. Microbes Infect. 2016 Feb;18(2):128-136. PMID: 26482505.

Ho YS, Tsai WH, Lin FC, et al. Cardioprotective actions of TGFbetaRI inhibition through stimulating autocrine/paracrine of survivin and inhibiting Wnt in cardiac progenitors. Stem Cells. 2016 Feb;34(2):445-455. PMID: 26418219.

Sun X, Kim YH, Phan TN, et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem. 2014;78(11):1805-1812. PMID: 25351330.

Nishino Y

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M4004

    MK-2461

    MET, FGFR, PDGFR inhibitor.

    ≥99%
  • N3422

    Nifekalant Hydrochloride

    Voltage-gated K+ channel blocker.

    ≥98%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • W0275

    R-(+)-Warfarin Sodium >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • O1078

    Octreotide Acetate

    Somatostatin analog, peptide; somatostatin agon...

    ≥95%
  • Z5745

    Zolmitriptan

    5-HT1B/1D agonist.

    ≥99%
  • V3253

    Vinblastine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥96%
  • E6996

    Erythromycin Thiocyanate

    Macrolide; protein translation inhibitor, mamma...

    ≥90%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • P0092

    Paclitaxel, from Taxus yunnanensis

    Diterpene found in Taxus yunnanensis; microtubu...

    ≥98%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.

    ≥98%
  • B6902

    B-Raf IN 1

    B-Raf and c-Raf inhibitor.

    ≥98%
  • F4683

    Fluticasone Propionate

    β2-adrenergic agonist.

    ≥98%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.

    ≥98%
  • I5213

    Indole-3-carbinol

    Indole, glucosinolate found in cruciferous vege...

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • E6997

    Erythropoietin, Human Recombinant

    Endogenous glycoprotein hormone involved in red...

    ≥97%