LKT Labs

Biochemicals for Life Science Research

Adrenocorticotropic Hormone (1-10), human

Adrenocorticotropic Hormone (1-10), human

Product ID A0963
Cas No. 2791-05-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $65.00 In stock
2 mg $111.00 In stock
5 mg $196.00 In stock
Bulk Quote

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Description

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory activities. ACTH decreases inflammatory cytokine levels and modulates lymphocyte and macrophage functions. In vitro, ACTH stimulates proliferation of osteoblasts and increases mRNA levels of collagen I.

Product Info

Cas No.

2791-05-1
Purity

≥95%
Formula

C59H78N16O16S
Formula Wt.

1299.4
IUPAC Name

(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Synonym

ACTH
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A0963 MSDS PDF
Info Sheet

A0963 Info Sheet PDF

References

Berkovich R, Agius MA. Mechanisms of action of ACTH in the management of relapsing forms of multiple sclerosis. Ther Adv Neurol Disord. 2014 Mar;7(2):83-96. PMID: 24587825.

Isales CM, Zaidi M, Blair HC. ACTH is a novel regulator of bone mass. Ann N Y Acad Sci. 2010 Mar;1192:110-6. PMID: 20392225.

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