Adrenorphin

Product ID A1371

Cas No.

Purity ≥95%

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Product Info
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References

Description
Product Info
Shipping and Storage
Downloads
References
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Description

Adrenorphin is an endogenous opioid peptide produced from cleavage of proenkephalin A. Adrenorphin acts as an agonist at κ-opioid receptors (κORs) and μ-opioid receptors (μORs). Like other opioids, adrenorphin exhibits analgesic, antinociceptive, and gastrointestinal motility modulating activities. Adrenorphin also causes respiratory depression in animal models. In pheochromocytoma cells, adrenorphin inhibits catecholamine secretion. In animal models, it also inhibits urinary bladder muscle contractions.

Product Info

Purity	≥95%
Formula	C₄₄H₆₉N₁₅O₉S
Formula Wt.	984.2
IUPAC Name	(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-N-[(2R)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-(diaminomethylideneamino)pentanamide
Synonym	Metorphamide
Solubility	Soluble in water.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A1371 MSDS PDF
Info Sheet	A1371 Info Sheet PDF

References

Yanase T, Nawata H, Kato K,et al. Studies on adrenorphin in pheochromocytoma. J Clin Endocrinol Metab. 1987 Apr;64(4):692-7. PMID: 3818899.

Xu SF, Lu WX, Zhou KR, et al. The analgesic and respiratory depressant actions of metorphamide in mice and rabbits. Neuropeptides. 1985 Apr;6(2):121-31. PMID: 4000426.

Dray A, Davis TP. The proenkephalin A fragment metorphamide shows supraspinal and spinal opioid activity in vivo. Peptides. 1985 Mar-Apr;6(2):217-21. PMID: 3839922.

Weber E, Esch FS, Böhlen P, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6. PMID: 6316361.