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AG-1024 is a tyrphostin that inhibits IGF-1R, exhibiting anticancer chemotherapeutic activity. In hepatocellular carcinoma cells and breast cancer cells, AG-1024 increases levels of cytochrome C, decreases activation of ERK, and inhibits invasion and proliferation.
| Cas No. | 65678-07-1 |
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| Purity | ≥98% |
| Formula | C14H13BrN2O |
| Formula Wt. | 305.17 |
| Chemical Name | 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| IUPAC Name | 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| Synonym | AG1024 (tyrphostin) |
| Solubility | DMSO 61 mg/mL (199.88 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Light tan to light orange solid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Yao WF, Liu JW, Sheng GL, et al. Blockade of IGF-IR exerts anticancer effects in hepatocellular carcinoma. Mol Med Rep. 2011 Jul-Aug;4(4):719-22. PMID: 21567089.
Chakraborty AK, Welsh A, Digiovanna MP. Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines. Breast Cancer Res Treat. 2010 Apr;120(2):327-35. PMID: 19337828.