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Alfacalcidol

Alfacalcidol

Product ID A4521
Cas No. 41294-56-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $90.30 In stock
5 mg $225.40 In stock
25 mg $631.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Alfacalcidol is a vitamin D analog that requires 25-hydroxylation to become the active hormonal form of vitamin D3. Alfacalcidol is clinically used to treat osteoporosis, hyperparathyroidism, and renal bone disease. As an anti-osteoporotic, alfacalcidol increases bone strength and formation and displays anti-catabolic and anabolic effects on bone in vivo.

Product Info

Cas No.

41294-56-8

Purity

≥98%

Formula

C27H44O2

Formula Wt.

400.64

IUPAC Name

(1R,3S,5E)-5-[(2Z)-2-[(1R,3aS, 7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6, 7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1, 3-diol

Synonym

1-Hydroxyvitamin D3, 1-Hydroxycholecalciferol (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol

Melting Point

136°C

Solubility

Soluble in THF and methanol.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4521 MSDS PDF

Info Sheet

A4521 Info Sheet PDF

References

Mazzaferro S, Goldsmith D, Larsson TE, et al. Vitamin D Metabolites and/or Analogs: Which D for Which Patient? Curr Vasc Pharmacol. 2014 Mar;12(2):339-49. PMID: 23713876.

Hara S, Kishimoto KN, Okuno H, et al. Effects of alfacalcidol on back extensor strength gained through back extensor exercise in postmenopausal women with osteoporosis. Am J Phys Med Rehabil. 2013 Feb;92(2):101-10. PMID: 23044701.

Chen H, Tian X, Liu X, et al. Alfacalcidol-stimulated focal bone formation on the cancellous surface and increased bone formation on the periosteal surface of the lumbar vertebrae of adult female rats. Calcif Tissue Int. 2008 Feb;82(2):127-36. PMID: 18175034.

Custom Order

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