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Amyloid-β (1-40)

Amyloid-β (1-40)

Product ID A4848
Cas No. 131438-79-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $824.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amyloid-β (Aβ) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aβ oligomers instigate conformation changes in other, normally folded Aβ oligomers, increasing the number of misfolded proteins and eventually forming neurotoxic plaques. These plaques impair cognitive performance in vivo. Aβ (1-42) is more fibrillogenic and more highly associated with Alzheimer’s disease than Aβ (1-40), although the shorter form is more common.

Product Info

Cas No.

131438-79-4

Purity

≥98%

Formula

C194H295N53O58S

Formula Wt.

4329.8

Synonym

Amyloid-beta protein fragment (1-40)

Solubility

Soluble in water (~6mg/mL). Not directly soluble in buffer or saline.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4848 MSDS PDF

Info Sheet

A4848 Info Sheet PDF

References

Hu J, el-Fakahany EE. Neuroreport. 4(6):760-762 (1993).Jia J, Kang L, Li S, et al. Amelioratory effects of testosterone treatment on cognitive performance deficits induced by soluble Aβ1-42 oligomers injected into the hippocampus. Horm Behav. 2013 Aug;64(3):477-86. PMID: 23954394.

Yin YI, Bassit B, Zhu L, et al. gamma-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: Implications for Alzheimer Disease. J Biol Chem. 2007 Aug 10;282(32):23639-44. PMID: 17556361.

Hartmann T, Bieger SC, Brühl B, et al. Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med. 1997 Sep;3(9):1016-20. PMID: 9288729.

Custom Order

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