LKT Labs

Biochemicals for Life Science Research

Atorvastatin Calcium Trihydrate

Atorvastatin Calcium Trihydrate

Product ID A7658
Cas No. 344423-98-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
50 mg $207.50 In stock
100 mg $321.90 In stock
Bulk Quote

Quicklinks

Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

Product Info

Cas No.

344423-98-9
Purity

≥98%
Formula

(C33H34FN2O5)2Ca • 3H2O
Formula Wt.

1209.39
Chemical Name

(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid

IUPAC Name

calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate
Synonym

Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator
Melting Point

159-161°C

Solubility

Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml)
Appearance

Off White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A7658 MSDS PDF
Info Sheet

A7658 Info Sheet PDF

References

Cai J, Yu X, Zhang B, et al. Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury. Am J Nephrol. 2014;39(6):466-75. PMID: 24854145.

Akahori H, Tsujino T, Naito Y, et al. Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. J Hypertens. 2014 Jul;32(7):1534-41. PMID: 24759122.

Lea AP, McTavish D. Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47. PMID: 9129869.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • C1633

    Cefotaxime Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥96%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • S8145

    Sulindac

    NSAID; COX-1/2 and PDE inhibitor.

    ≥99%
  • W4096

    WKYMVM-NH2

    Synthetic peptide; FPRL1 agonist.

    ≥95%
  • A145823

    ADU-S100 sodium salt

    Synthetic cyclic dinucleotide agonist of STING....

    ≥99%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • P4403

    Plasminogen Activator Inhibitor 1

    Endogenous peptide, produced by activation of P...

    ≥95%
  • R2713

    Recombinant HCV-NS4 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • D490280

    DMH-1

    Inhibitor of BMP.

    ≥99%
  • A081014

    Acalabrutinib

    Inhibitor of Bruton’s tyrosine kinase (BTK).<...

    ≥99%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibito...

    ≥98%
  • E6398

    EPZ-5676

    DOT1L HMT inhibitor.

    ≥98%
  • M5876

    Motesanib

    VEGFR1/2/3, PDGFR, c-Kit, RET inhibitor.

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • C8112

    CUDC-907

    PI3K and HDAC inhibitor.

    ≥98%
  • G4781

    Glucoraphanin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%