LKT Labs

Biochemicals for Life Science Research

AZD-7762 Hydrochloride

AZD-7762 Hydrochloride

Product ID A9912
Cas No. 1246094-78-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $177.20 In stock
10 mg $278.60 In stock
Bulk Quote

Quicklinks

Description

AZD-7762 is an inhibitor of checkpoint kinase (CHK) 1 that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for a variety of cancers. In breast cancer and ovarian cancer cells, AZD-7762 inhibits cellular proliferation. In animal models of breast cancer, AZD-7762 inhibits tumor growth and increases survival rates. This compound displays somewhat limited efficacy due to cardiac toxicity.

Product Info

Cas No.

1246094-78-9
Purity

≥98%
Formula

C17H19FN4O2S • HCl
Formula Wt.

398.88
IUPAC Name

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
Synonym

AZD-7762 HCl
Solubility

DMSO 50 mg/mL (137.96 mM) Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9912 MSDS PDF
Info Sheet

A9912 Info Sheet PDF

References

Bryant C, Rawlinson R, Massey AJ. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. BMC Cancer. 2014 Aug 7;14:570. PMID: 25104095.

Sausville E, Lorusso P, Carducci M, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):539-49. PMID: 24448638.

Ma CX, Cai S, Li S, et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr;122(4):1541-52. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702. PMID: 22446188.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9879

    Cytochalasin B

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • G7443

    GSK-429286A

    ROCK1/2 inhibitor, potential RSK and p70S6K inh...

    ≥98%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy homeo...
    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • M3598

    Mizoribine Hydrobromide

    IMPDH inhibitor.

    ≥98%
  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • B6957

    Bromhexine Hydrochloride

    Synthetic derivative of vasicine, mucolytic.

    ≥98%
  • I525138

    Indoximod

    Indoleamine 2,3-dioxygenase inhibitor.

    ≥98%
  • S1970

    Serum Thymic Factor

    Synthetic peptide hormone.

    ≥95%
  • P0392

    Paxilline

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • T286161

    Theaflavin

    Polyphenolic compound present in black tea.

    ≥98%
  • F4481

    Flurbiprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • L8011

    D-Luciferin Sodium

    Heterocyclic light-emitting compound, natural l...

    ≥99%
  • P2815

    Phenylbutyrate Sodium

    HDAC inhibitor.

    ≥98%
  • D019601

    Dapagliflozin

    SGLT2 inhibitor

    ≥98%
  • T5869

    Torcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • T6930

    Triclosan Methyl Ether

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥99%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%