AZD-7762 Hydrochloride

Name: AZD-7762 Hydrochloride
SKU: A9912
Availability: InStock

Product ID A9912

Cas No. 1246094-78-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

AZD-7762 is an inhibitor of checkpoint kinase (CHK) 1 that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for a variety of cancers. In breast cancer and ovarian cancer cells, AZD-7762 inhibits cellular proliferation. In animal models of breast cancer, AZD-7762 inhibits tumor growth and increases survival rates. This compound displays somewhat limited efficacy due to cardiac toxicity.

Product Info

Cas No.	1246094-78-9
Purity	≥98%
Formula	C₁₇H₁₉FN₄O₂S • HCl
Formula Wt.	398.88
IUPAC Name	3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
Synonym	AZD-7762 HCl
Solubility	DMSO 50 mg/mL (137.96 mM) Water Insoluble Ethanol Insoluble
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A9912 MSDS PDF
Info Sheet	A9912 Info Sheet PDF

References

Bryant C, Rawlinson R, Massey AJ. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. BMC Cancer. 2014 Aug 7;14:570. PMID: 25104095.

Sausville E, Lorusso P, Carducci M, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):539-49. PMID: 24448638.

Ma CX, Cai S, Li S, et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr;122(4):1541-52. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702. PMID: 22446188.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

AZD-7762 Hydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Quizartinib

4-tert-Butyl-5-Methoxycatechol

Bergenin

JZL184

Veratramine

Erlotinib Hydrochloride

Lonidamine

Alamethicin

Dantrolene Sodium Heptahydrate

Levo-Chloramphenicol

Ginkgolide J

β-Zearalanol

Angiotensin I/II (1-7)(DP-7)

Filipin Complex

Thiostrepton

Snake venom – Bothrops neuwiedi diporous

Cafestol Acetate

Ovalbumin Fragment (257-264)

Itraconazole

Spironolactone

Footer