LKT Labs

Biochemicals for Life Science Research

AZD-7762 Hydrochloride

AZD-7762 Hydrochloride

Product ID A9912
Cas No. 1246094-78-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $177.20 In stock
10 mg $278.60 In stock
Bulk Quote

Quicklinks

Description

AZD-7762 is an inhibitor of checkpoint kinase (CHK) 1 that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for a variety of cancers. In breast cancer and ovarian cancer cells, AZD-7762 inhibits cellular proliferation. In animal models of breast cancer, AZD-7762 inhibits tumor growth and increases survival rates. This compound displays somewhat limited efficacy due to cardiac toxicity.

Product Info

Cas No.

1246094-78-9
Purity

≥98%
Formula

C17H19FN4O2S • HCl
Formula Wt.

398.88
IUPAC Name

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
Synonym

AZD-7762 HCl
Solubility

DMSO 50 mg/mL (137.96 mM) Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9912 MSDS PDF
Info Sheet

A9912 Info Sheet PDF

References

Bryant C, Rawlinson R, Massey AJ. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. BMC Cancer. 2014 Aug 7;14:570. PMID: 25104095.

Sausville E, Lorusso P, Carducci M, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):539-49. PMID: 24448638.

Ma CX, Cai S, Li S, et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr;122(4):1541-52. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702. PMID: 22446188.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1952

    Tenuazonic Acid Copper Salt

    Mycotoxin produced by Alternaria; photosynthesi...

    ≥98%
  • E9416

    Exendin-3

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • U451349

    Ulixertinib

    May induce apoptosis in lymphoma cell lines.

    ≥98%
  • P2510

    4-Phenylbutylisothiocyanate

    Synthetic ITC.

    ≥98%
  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • C3260

    Ciprofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • S3346

    Silodosin

    α1A-adrenergic antagonist.

    ≥98%
  • L961000

    LY-3295668

    Aurora kinase A inhibitor

    ≥99%
  • I5992

    IOX2

    Prolyl hydroxylase inhibitor.

    ≥98%
  • S4932

    SMI-4a

    Thiazolidine; Pim kinase inhibitor.

    ≥99%
  • A1332

    Adipokinetic Hormone II from Locusta migratoria

    Neuropeptide found in Locusta migratoria.

    ≥98%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • D1769

    Dermorphin

    Opioid peptide; μOR agonist.

    ≥96%
  • R8206

    Rubescensin A

    Diterpene originally found in Rabdosia.

    ≥93%
  • A7656

    Atomoxetine Hydrochloride

    NET and SERT inhibitor, NMDA antagonist.

    ≥99%
  • G124084

    GDC-0973

    MEK1 inhibitor.

    ≥99%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

    ≥98%
  • A491337

    9-Aminocamptothecin Hydrochloride

    Derivative of camptothecin.

    ≥98%
  • A9603

    5-Aza-2′-deoxycytidine

    Nucleoside (deoxycytidine) analog; DNMT inhibit...

    ≥98%