• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AZD-7762 Hydrochloride

AZD-7762 Hydrochloride

Product ID A9912
Cas No. 1246094-78-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $177.20 In stock
10 mg $278.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-7762 is an inhibitor of checkpoint kinase (CHK) 1 that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for a variety of cancers. In breast cancer and ovarian cancer cells, AZD-7762 inhibits cellular proliferation. In animal models of breast cancer, AZD-7762 inhibits tumor growth and increases survival rates. This compound displays somewhat limited efficacy due to cardiac toxicity.

Product Info

Cas No.

1246094-78-9

Purity

≥98%

Formula

C17H19FN4O2S • HCl

Formula Wt.

398.88

IUPAC Name

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride

Synonym

AZD-7762 HCl

Solubility

DMSO 50 mg/mL (137.96 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9912 MSDS PDF

Info Sheet

A9912 Info Sheet PDF

References

Bryant C, Rawlinson R, Massey AJ. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. BMC Cancer. 2014 Aug 7;14:570. PMID: 25104095.

Sausville E, Lorusso P, Carducci M, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):539-49. PMID: 24448638.

Ma CX, Cai S, Li S, et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr;122(4):1541-52. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702. PMID: 22446188.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0095

    Baccatin III

    Diterpene found in Taxus, used to synthesize ta...

    ≥98%
  • A046189

    Abexinostat

    Primarily targets HDAC1

    ≥98%
  • U6901

    Uracil

    Endogenous pyrimidine base required for product...

    ≥98%
  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • C167200

    Cefazolin

    Cephalosporin analogue

    ≥98%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.

    ≥98%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen

  • A9601

    AZD-5363

    AKT inhibitor, potential ROCK, p70S6K, PKA, MKK...

    ≥99%, ≥99%ee
  • I7870

    Itraconazole

    Triazole; 14-α demethylase inhibitor, Smo modu...

    ≥98%
  • T1678

    D,L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective....

    ≥98%
  • B5870

    Borrelidin

    Macrolide; threonyl-tRNA synthetase/ligase inhi...

    ≥99%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • B1855

    O6-Benzylguanine

    MGMT inhibitor.

    ≥98%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • P7103

    Praziquantel

    Alters membrane permeability and Ca2+ signaling...

    ≥98%
  • R2353

    RF-NH2

    RF-amide peptide; potential GPR147 agonist, pot...

    ≥95%
  • C3576

    Citreoviridin A

    Mycotoxin; F1F0 ATP synthase inhibitor.

    ≥95%
  • S0045

    Salbutamol Sulfate

    β2-adrenergic agonist.

    ≥98%
  • H1673

    Hesperidin

    Flavonoid found in species of Citrus; COX-2 inh...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only