• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AZD-8186

AZD-8186

Product ID A985132
Cas No. 1627494-13-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $75.00 In stock
25 mg $238.60 In stock
100 mg $749.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ. It shows efficacy against PTEN-null tumors, which become dependent on the PI3Kβ isoform. The loss of the PTEN protein results in upregulation of the PI3K/AKT pathway, making small molecules that target PI3Kβ viable in cancers like PTEN-deficient breast and prostate tumors.

Product Info

Cas No.

1627494-13-6

Purity

≥99%

Formula

C24H25F2N3O4

Formula Wt.

457.48

IUPAC Name

8-{(1R)-1-[(3,5-Difluorophenyl)amino]ethyl}-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-chromene-6-carboxamide

Synonym

AZD 8186, AZD8186

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A985132 MSDS PDF

Info Sheet

A985132 Info Sheet PDF

References

Barlaam B., Cosulich S., et al. Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers. J Med Chem. 58(2):943-62 (2015). PMID: 25514658.

Lynch J., Planska U., et al. Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors. Clin Cancer Res. 23(24):7584-95 (2017). PMID: 28972046.

Hancox U., Cosulich S., et al. Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel. Mol Cancer Ther. 14(1):48-58 (2015). PMID: 25398829.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M0040

    M40

    Peptide; galanin antagonist.

    ≥95%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • D324096

    Diclofenac Impurity B

    Impurity of diclofenac

    ≥98%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%
  • C0269

    β-Carotene

    Red-orange terpene pigment found in various pla...

    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A ...

    ≥98%
  • I5210

    INCB018424

    JAK1/2 inhibitor.

    ≥98%
  • E5217

    β-Endorphin, human

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.

    ≥98%
  • C5782

    Coumarin

    Benzopyrone found in various plants, precursor ...

    ≥98%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • A0960

    Adrenocorticotropic Hormone (1-39), human

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • L8011

    D-Luciferin Sodium

    Heterocyclic light-emitting compound, natural l...

    ≥99%
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • E6846

    Erlotinib Hydrochloride

    EGFR inhibitor.

    ≥98%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • F5872

    N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • I7558

    1-Isothiocyanato-9-(methylsulfenyl)-nonane

    ITC, erucin analog.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only