Description
BML-277 (Chk2 Inhibitor II) is an arylbenzimidazole inhibitor of checkpoint kinase (CHK) 2. This compound displays cytoprotective activity, protecting CD4+ and CD8+ T cells against radiation-induced apoptosis.
BML-277
Product ID B5044
Cas No. 516480-79-8
Purity ≥98%
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Product Info
| Cas No. | 516480-79-8 |
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| Purity | ≥98% |
| Formula | C20H14ClN3O2 |
| Formula Wt. | 363.80 |
| Chemical Name | 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide |
| IUPAC Name | 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide |
| Synonym | Chk2 Inhibitor II |
| Solubility | DMSO 72 mg/mL Ethanol 21 mg/mL Water Insoluble |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Arienti KL, Brunmark A, Axe FU, et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. PMID: 15771432.