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Cabazitaxel is a semi-synthetic taxoid that is an effective antineoplastic agent used in the treatment of prostate cancer and breast cancer. Cabazitaxel is shown to disrupt the microtubular network in cells that exhibit P-glycoprotein (Pgp) mediated drug resistance. Its poor affinity for Pgp makes it a more effective therapeutic agent than docetaxel in cancer cells that become resistant to the taxane class of cancer drugs.
| Cas No. | 183133-96-2 |
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| Purity | ≥98% |
| Formula | C45H57NO14 |
| Formula Wt. | 835.94 |
| Chemical Name | 1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-ene-2,4,13-triyl 4-acetate 2-benzoate 13-((2R,3S)-3-(((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate) |
| IUPAC Name | (2α,5β,7β,10β,13α)-4-Acetoxy-1-hydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| Synonym | XPR-6258, TXD 258, Taxoid XRP6258, RPR 116258A, jevtana. |
| Solubility | Soluble in DMSO (~100 mg/mL), ethanol (~50 mg/mL). Sparingly soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.