Carvedilol Phosphate Hemihydrate

Name: Carvedilol Phosphate Hemihydrate
SKU: C0366
Availability: InStock

Product ID C0366

Cas No. 610309-89-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Carvedilol phosphate is a cardioprotective α1- and β1/2-adrenergic receptor inhibitor used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol phosphate also inhibits release of pro-inflammatory cytokines TNF-α and IL-6 and production of eicosanoids PGE2 and LTB4, alleviating oxidative stress and indicating antioxidative and anti-inflammatory activities. Additionally, this compound may exhibit anti-atherosclerotic and anti-diabetic activity through its inhibition of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	610309-89-2
Purity	≥98%
Formula	C₂₄H₂₆N₂O₄ • H₃O₄P • 1/2H₂O
Formula Wt.	513.47
Chemical Name	(2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate
IUPAC Name	1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;phosphoric acid;hydrate
Solubility	Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37° C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C0366 MSDS PDF
Info Sheet	C0366 Info Sheet PDF

References

Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Carvedilol Phosphate Hemihydrate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

PF-06873600

Secretin, rat

Vatalanib

Cafestol Eicosanate

HIV Reverse Transcriptase A2.1 Peptide

Nisoldipine

Dolasetron

Neuromedin U, rat

Triticonazole

Ursodeoxycholic Acid

Zafirlukast

Isorhamnetin

Lorglumide Sodium

N,N-Dimethyl-Sphingosine

ELR-510444

Ginkgolide C

Daunorubicin Hydrochloride

Tivozanib

Taxol Side Chain Acid

6-Gingerol

Footer