Carvedilol Phosphate Hemihydrate

Name: Carvedilol Phosphate Hemihydrate
SKU: C0366
Availability: InStock

Product ID C0366

Cas No. 610309-89-2

Purity ≥98%

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Description

Carvedilol phosphate is a cardioprotective α1- and β1/2-adrenergic receptor inhibitor used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol phosphate also inhibits release of pro-inflammatory cytokines TNF-α and IL-6 and production of eicosanoids PGE2 and LTB4, alleviating oxidative stress and indicating antioxidative and anti-inflammatory activities. Additionally, this compound may exhibit anti-atherosclerotic and anti-diabetic activity through its inhibition of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	610309-89-2
Purity	≥98%
Formula	C₂₄H₂₆N₂O₄ • H₃O₄P • 1/2H₂O
Formula Wt.	513.47
Chemical Name	(2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate
IUPAC Name	1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;phosphoric acid;hydrate
Solubility	Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37° C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C0366 MSDS PDF
Info Sheet	C0366 Info Sheet PDF

References

Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

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Carvedilol Phosphate Hemihydrate

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Description

Product Info

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Downloads

References

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