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Caspofungin Diacetate

Caspofungin Diacetate

Product ID C0274
Cas No. 179463-17-3
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $102.30 In stock
25 mg $375.60 In stock
100 mg $1,172.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Caspofungin acetate is a lipopeptide antifungal that inhibits the enzyme 1,3-β-Glucan synthase, which synthesizes β-glucan polymers that form fungal cell walls. Caspofungin acetate is active against a variety of Aspergillus and Candida species and unlike many antifungals, is not metabolized by the cytochrome p450 system. The ability of caspofungin acetate to inhibit β-glucan synthesis decreases cell wall mechanical strength, alters cell surface hydrophobicity, and triggers cell aggregation.

Product Info

Cas No.

179463-17-3

Purity

≥95%

Formula

C52H88N10O15 • C4H8O4

Formula Wt.

1213.42

IUPAC Name

acetic acid;N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide

Synonym

Caspofungin Acetate, MK-0991

Melting Point

204-206°C

Solubility

Soluble in ethanol (20 mg/mL), DMSO (25 mg/mL), DMF (20 mg/mL), water (10 mg/mL), methanol.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0274 MSDS PDF

Info Sheet

C0274 Info Sheet PDF

References

El-Kirat-Chatel S, Beaussart A, Alsteens D, et al. Nanoscale analysis of caspofungin-induced cell surface remodelling in Candida albicans. Nanoscale. 2013 Feb 7;5(3):1105-15. PMID: 23262781.

Pacetti SA, Gelone SP. Caspofungin acetate for treatment of invasive fungal infections. Ann Pharmacother. 2003 Jan;37(1):90-8. PMID: 12503942.

Mio T, Adachi-Shimizu M, Tachibana Y, et al. Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis. J Bacteriol. 1997 Jul;179(13):4096-105. PMID: 9209021.

Custom Order

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