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Ceftiofur is a third generation β-lactam antibacterial used in livestock. Like other similar antibiotics, ceftiofur inhibits synthesis of bacterial cell walls by inhibiting penicillin binding proteins. Ceftiofur also displays anti-inflammatory activity. In vivo, this compound decreases LPS-induced expression of IL-1β, IL-6, and TNF-α, exhibiting potential in the treatment of endotoxemia.
| Cas No. | 103980-44-5 |
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| Purity | ≥90% |
| Formula | C19H17N5O7S3 • HCl |
| Formula Wt. | 560.02 |
| Chemical Name | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7- (((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2- furanylcarbonyl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))- |
| IUPAC Name | sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylate |
| Synonym | Excenel, Ceftiofurum, Vetranal |
| Solubility | Insoluble in water |
| Appearance | White to off-white crystalline powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Li X, Zheng W, Machesky ML, et al. Degradation kinetics and mechanism of antibiotic ceftiofur in recycled water derived from a beef farm. J Agric Food Chem. 2011 Sep 28;59(18):10176-81. PMID: 21863813.
Ci X, Li H, Song Y, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31(6):422-7. PMID: 18989766.