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Cephalomannine

Cephalomannine

Product ID T0096
Cas No. 71610-00-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $322.00 In stock
10 mg $510.80 In stock
25 mg $1,135.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cephalomannine is a diterpene found in Taxus that exhibits anticancer and nephroprotective activities. Cephalomannine may display anticancer activity through binding of tubulin although current research is limited. This compound suppresses cell growth of neuroblastoma and glioblastoma cells and inhibits activity of DNA polymerase. In animal models of polycystic kidney disease, cephalomannine promotes microtubule assembly and increases survival rates.

 

Product Info

Cas No.

71610-00-9

Purity

≥98%

Formula

C45H53NO14

Formula Wt.

831.91

IUPAC Name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-1,9-dihydroxy-15-[(2R,3S)-2-hydroxy-3-[[(E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Synonym

Taxol B

Solubility

Soluble in DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0096 MSDS PDF

Info Sheet

T0096 Info Sheet PDF

References

Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.

Custom Order

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