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Chlorophyllin Sodium-Copper Salt

Chlorophyllin Sodium-Copper Salt

Product ID C2945
Cas No. 11006-34-1
Purity USP 28
Product Unit SizeCostQuantityStock
5 g $39.90 In stock
25 g $99.80 In stock
100 g $288.80 Please Inquire
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

Chlorophyllin is a semi-synthetic derivative of chlorophyll that is commercially used as a food additive and coloring agent. Chlorophyllin exhibits anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Chlorophyllin can act as a photosensitizer, inducing apoptosis and autophagy under UV light in bladder cancer cells. In vivo, chlorophyllin decreases expression of HDACs, VEGF, VEGFR2, and HIF-1α and suppresses Wnt/β-catenin signaling. In vitro, this compound decreases DNA adduct formation induced by benzo[a]pyrene. Chlorophyllin also decreases carcinogenesis, mortality, and tumor number in animal models of DBP-induced carcinogenesis.

Product Info

Cas No.

11006-34-1

Purity

USP 28

Formula

C34H31CuN4Na3O6

Formula Wt.

724.15

IUPAC Name

magnesium;3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl- 13-ethyl-3,7,12,17-tetramethyl-2, 3-dihydroporphyrin-23-id-2-yl]propanoate;hydron

Synonym

Chlorophyllin A

Solubility

Soluble in water, slightly soluble in alcohol and chloroform.

Appearance

Dark green powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C2945 MSDS PDF

Info Sheet

C2945 Info Sheet PDF

Brochures

WNT Booklet

References

Lihuan D, Jingcun Z, Ning J, et al. Photodynamic therapy with the novel photosensitizer chlorophyllin f induces apoptosis and autophagy in human bladder cancer cells. Lasers Surg Med. 2014 Apr;46(4):319-34. PMID: 24464873.

Nagini S, Vidya Priyadarsini R, Veeravarmal V, et al. Chlorophyllin abrogates canonical Wnt/β-catenin signaling and angiogenesis to inhibit the development of DMBA-induced hamster cheek pouch carcinomas. Cell Oncol (Dordr). 2012 Oct;35(5):385-95. Erratum in: Cell Oncol (Dordr). 2013 Apr;36(2):179. PMID: 22983718.

Keshava C, Divi RL, Einem TL, et al. Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells. Environ Mol Mutagen. 2009 Mar;50(2):134-44. PMID: 19152381.

Castro DJ, Löhr CV, Fischer KA, et al. Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis. 2009 Feb;30(2):315-20. PMID: 19073876.

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