Description
Clioquinol is an antifungal agent that has exhibited neuroprotective and anticancer properties. It is a metal ionophore that inhibits growth of pathogenic fungi including strains of Candida and Aspergillus.
Treatment using clioquinol in models of Huntington’s disease in mice resulted in improved behavioral and pathologic phenotypes and extension of life span. The structural and functional features of clioquinol as a metal chelating aggregation modulator have been adapted in combination with epigallocatechin gallate to create a hybrid modulator that prevents the generation of reactive oxygen species and interrupting the interaction of toxic amyloid-beta species with mitochondria, making it a potential treatment for Alzheimer’s disease.