Crizotinib

Name: Crizotinib
SKU: C6935
Availability: InStock

Product ID C6935

Cas No. 877399-52-5

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Crizotinib is an inhibitor of anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and c-MET, binding competitively to the ATP-binding pocket of kinases. Crizotinib exhibits anticancer chemotherapeutic benefit in the treatment of non-small cell lung cancer (NSCLC) and is currently in clinical trials as a potential treatment for neuroblastoma and other advanced solid tumors. In cellular models, this compound upregulates expression of pro-apoptotic BIM and downregulates expression of anti-apoptotic survivin to induce apoptosis and inhibit cell proliferation.

Product Info

Cas No.	877399-52-5
Purity	≥98%
Formula	C₂₁H₂₂Cl₂FN₅O
Formula Wt.	450.34
Chemical Name	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
IUPAC Name	3-[(1R)-1-(2, 6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl) pyridin-2-amine
Synonym	Xalkori
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C6935 MSDS PDF
Info Sheet	C6935 Info Sheet PDF

References

Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Crizotinib

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Thienyloctyl Isothiocyanate

Temozolomide

Benzydamine Hydrochloride

Ampicillin Trihydrate

GBR-12909 Dihydrochloride

Snake venom – Bothrops neuwiedi diporous

Nonactin

Bleomycin A5 Hydrochloride Cu

Adrenocorticotropic Hormone (18-39), human

Neurokinin B

Okadaic Acid

Y27632 Dihydrochloride

Theophylline

(S)-ar-Turmerone

Sarcophine

Neomycin Sulfate

GBR 12935 Dihydrochloride

Irsogladine Maleate

2,3,5,6-Tetramethylpyrazine

Oleanolic Acid

Footer