LKT Labs

Biochemicals for Life Science Research

Crizotinib

Crizotinib

Product ID C6935
Cas No. 877399-52-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
10 mg $153.10 In stock
25 mg $337.10 In stock
100 mg $816.70 In stock
Bulk Quote

Quicklinks

Description

Crizotinib is an inhibitor of anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and c-MET, binding competitively to the ATP-binding pocket of kinases. Crizotinib exhibits anticancer chemotherapeutic benefit in the treatment of non-small cell lung cancer (NSCLC) and is currently in clinical trials as a potential treatment for neuroblastoma and other advanced solid tumors. In cellular models, this compound upregulates expression of pro-apoptotic BIM and downregulates expression of anti-apoptotic survivin to induce apoptosis and inhibit cell proliferation.

Product Info

Cas No.

877399-52-5
Purity

≥98%
Formula

C21H22Cl2FN5O
Formula Wt.

450.34
Chemical Name

3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
IUPAC Name

3-[(1R)-1-(2, 6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl) pyridin-2-amine
Synonym

Xalkori
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C6935 MSDS PDF
Info Sheet

C6935 Info Sheet PDF

References

Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P6865

    Propranolol Hydrochloride

    β1/2-adrenergic antagonist.

    ≥98%
  • D5690

    Doxazosin Mesylate

    Quinazoline; α1-adrenergic antagonist.

    ≥98%
  • N8660

    NVP-AUY922

    Isoxazole derivative; HSP90 inhibitor.

    ≥98%
  • C3576

    Citreoviridin A

    Mycotoxin; F1F0 ATP synthase inhibitor.

    ≥95%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • C2540

    CGK 733

    ATM and ATR inhibitor.

    ≥98%
  • C6982

    Crustacean Cardioactive Peptide

    Neuropeptide hormone found in arthropods.

    ≥95%
  • M0272

    Mastoparan 7

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • I0480

    Ibudilast

    PDE3/5 inhibitor, LTD4 antagonist.

    ≥98%
  • T2930

    Thiabendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • S3353

    Sinomenine Hydrochloride

    Alkaloid found in Sinomenium; acid-sensing ion ...

    ≥98%
  • T1952

    Tenuazonic Acid Copper Salt

    Mycotoxin produced by Alternaria; photosynthesi...

    ≥98%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • T3032

    Thienyldecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • A5225

    α-ANP (1-28), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • P0254

    Panaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • P6800

    Pravastatin Lactone

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • E6782

    S-Equol

    Isoflavone, phytoestrogen found in soy; ER agon...

    ≥99%
  • A6804

    Arbutin

    Glycoside hydroquinone originally found in Berg...

    ≥98%