Description
Cryptotanshinone is a quinoid diterpene found in species of Salvia that exhibits anticancer and anti-angiogenic activities. Cryptotanshinone directly inhibits dimerization of STAT3, disrupting STAT3 activation and signaling and inhibiting proliferation in glioma cells. This compound also induces G1/G0 phase cell cycle arrest and inhibits activation of mTOR, p70S6K, and eIF4eBP in rhabdomyosarcoma cells. Additionally, cryptotanshinone downregulates expression of VEGF and inhibits HIF-1α signaling, disturbing tube formation in vitro.